Modulatory role of substance P on gonadotropin and prolactin secretion in the rabbit

• Autorzy: Traczyk W Z , Pau K.Y.F. , Kaynard A.H. , Spies H.G.
• Języki publikacji: EN

Abstrakty

EN

Substance P (SP) is present in large quantities in the brainstem and hypophysiotropic areas of the brain, but its roles in gonadotropin and prolactin secretion are controversial. The aim of this study was to measure luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL) release from the pituitary after either intracerebroventricular (ICV) injection or infusion of SP or its C- and N-terminal fragments in intact (INT) and ovariectomized (OVX) conscious rabbits. A single injection of SP into the 3rd cerebral ventricle (3CVT) in INT and OVX rabbits augmented plasma LH concentrations, especially when SP was applied during the initial phase of an LH peak. Injection of SP during the declining phase of LH release was not effective. Injection of SP into the 3CVT was followed by increased plasma PRL concentrations in OVX but not in INT rabbits. Both SP 1-11 and SP 1-7 failed to alter LH, FSH, and PRL secretion when the peptides were slowly infused into the 3CVT, although ICV infusion of SP 6-11 did cause a delayed increase in LH release. The results support a stimulatory role of SP on LH and prolactin release. The results further indicate that although the stimulatory effect of SP on LH is ovarian steroid-independent, in the absence of ovarian steroids, SP is stimulatory only during the rising phase of an LH pulse. A dual role of SP-ergic transmission in modulating LH secretion is discussed.

Słowa kluczowe

EN

cerebral ventricle; blood plasma; prolactin; gonadotrophin; luteinizing hormone; rabbit; substance P; hormone

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1992
• Tom: 43
• Numer: 3
• Opis fizyczny: p.279-297,fig.

Twórcy

autor

Traczyk W Z

• Medical University of Lodz, ul.Lindleya 3, 90-131 Lodz, Poland

autor

Pau K.Y.F.

autor

Kaynard A.H.

autor

Spies H.G.

Bibliografia

• 1. Brownstein M, Mroz E, Kizer J, Palkovits M, Leeman S. Regional distribution of substance P in the brain of the rat. Brain Res 1976; 116: 299-305.
• 2. Aronin N, Coslovsky R, Leeman SE. Substance P and neurotensin: their roles in the regulation of anterior pituitary function. Ann Rev Physiol 1986; 48: 537-549.
• 3. Ronnekleiv OK, Kelly MJ, Eskay RL. Distribution of immunoreactive substance P neurons in the hypothalamus and pituitary of the rhesus monkey. J Comp Neurol 1984; 224: 51-59.
• 4. Chang MM, Leeman SE. Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P. J Biol Chem 1970; 245: 4784-4790.
• 5. Fisher GH, Humphries J, Folkers K, Pernow B, Bowers CY. Synthesis and some biological activities of substance P. J Med Chem 1974; 17: 843-846.
• 6. Arisawa M, De Palatis L, Ho R, et al. Stimulatory role of substance Pongonadotropin release in ovariectomized rats. Neuroendocrinology 1990; 51: 523-529.
• 7. Kato Y, Chihara K, Ohgo S, Iwasaki Y, Abe H, Imura H. Growth hormone and prolactin release by substance P in rats. Life Sciences 1976; 19: 441-446.
• 8. Rivier C, Brown M, Vale W. Effect of neurotensin, substance P and morphine sulfate on the secretion of prolactin and growth hormone in the rat. Endocrinology 1977; 100: 751-754.
• 9. Vijay an E, McCann SM. In vivo and in vitro effects of substance P and neurotensin on gonadotropin and prolactin release. Endocrinology 1979; 105: 64-68.
• 10. Chihara K, Arimura A, Coy DH, Schally AV. Studies on the interaction of endorphins, substance P, and endogenous somatostatin in growth hormone and prolactin release in rats. Endocrinology 1978; 102: 281-290.
• 11. Vijayan E, McCann SM. Effects of substance P and neurotensin on growth hormone and thyrotropin release in vivo and in vitro. Life Sciences 1980; 26: 321-327.
• 12. Eckstein N, Wehrenberg WB, Louis K, et al. Effects of substance P on anterior pituitary secretion in the female rhesus monkey. Neuroendocrinology 1980; 31: 338-342.
• 13. Picanco-Diniz DLW, Valenca MM, Franci CR, Antunes-Rodrigues J. Role of substance P in the medial preoptic area in the regulation of gonadotropin and prolactin secretion in normal or orchidectomized rats. Neuroendocrinology 1990; 51: 675-682.
• 14. Sawyer CH, Everett JW, Green JD. The rabbit diencephalon in stereotaxic coordinates. J Comp Neurol 1954; 101: 801-824.
• 15. Pau KYF, Spies HG. Effects of cupric acetate on hypothalamic gonadotropin-releasing hormone release in intact and ovariectomized rabbits. Neuroendocrinology 1986; 43: 197-204.
• 16. Orstead KM, Spies HG. Inhibition of hypothalamic gonadotropin-releasing hormone release by endogenous opioid peptides in the female rabbit. Neuroendocrinology 1987; 46: 14-23.
• 17. Khorram O, Pau KYF, Spies HG. Bimodal effects of neuropeptide Y on hypothalamic release of gonadotropin-releasing hormone in conscious rabbits. Neuroendocrinology 1987; 45: 290-297.
• 18. Pau KYF, Gliessman PM, Oyama T, Spies HG. Disruption of GnRH pulses by anti-GnRH serum and phentolamine obliterates pulsatile LH but not FSH secretion in ovariectomized rabbits. Neuroendocrinology 1991; 53: 382-391.
• 19. Ju G, Liu SJ, Zhang X. Peptidergic innervation of the pars distalis of the adenohypophysis. Neuroendocrinology 1991; 53 (suppl 1): 41-44.
• 20. Morel G, Chayvialle JA, Kerdelhue B, Dubois PM. Ultrastructural evidence for endogenous substance-P-like immunoreactivity in the rat pituitary gland. Neuroendocrinology 1982; 35: 86-92.
• 21. Magnusson T, Carlsson A, Fisher GH, Chang D, Folkers K. Effect of synthetic substance P on monoaminergic mechanisms in brain. J Neural Transmission 1976; 38: 89-93.
• 22. Pau KYF, Spies HG. Estrogen-dependent-effects of norepinephrine on hypothalamic gonadotropin-releasing hormone release in the rabbit. Brain Research 1986; 399: 15-23.
• 23. Traczyk WZ, Kubicki J. The pressor response to substance P and hexapeptide [pGlu⁶ ] SP₆₋₁₁ injections into the cerebral ventricles in rats. Neuropharmacology 1980; 19: 607-611.
• 24. Tsuruo Y, Kawano H, Hisano S, Kagotani Y, Daikoku S, Zhang T, Yanaihara N. Substance P- containing neurons innervating LHRH-containing neurons in the septo-preoptic area of rats. Neuroendocrinology 1991; 53: 236-245.