Synthesis and binding properties of deltorphin I analogues containing [R] and [S]-alpha-hydroxymethylnaphtylalanine

• Autorzy: Olma A. , Gniadzik A. , Lipkowski A.W. , Lachwa M.
• Języki publikacji: EN

Abstrakty

EN

New analogues of deltorphin I (DT I), in which the phenylalanine residue in position 3 is substituted with amphiphilic a,a-disubstituted amino acid enantiomers, (R) and (S)-a-hydroxymethylnaphtylalanine, were synthesized and tested for u and δ opioid re­ceptor affinity and selectivity. Although both analogues have lower affinity to δ recep­tors than DT I, they both expressed specificity to δ receptors.

Słowa kluczowe

EN

alpha-hydroksymethylamino acid; alpha,alpha-disubstituted amino acid; opioid peptide; deltorphin; opioid receptor binding; [S]-alpha-hydroxymethylnaphtylalanine; synthesis; binding property; amphiphilic amino acid; [R]-alpha-hydroxymethylnaphtylalanine

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1165-1168,fig.

Twórcy

autor

Olma A.

• Technical University of Lodz, Lodz, Poland

autor

Gniadzik A.

autor

Lipkowski A.W.

autor

Lachwa M.

Bibliografia

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