Expression of Npc1 in glial cells corrects sterility in Npc1 mice

• Autorzy: Donohue C , Marion S , Erickson R P
• Języki publikacji: EN

Abstrakty

EN

Niemann-Pick type C1 (NPC) disease is an autosomal recessive neurodegenerative disorder. One feature of the mouse model of NPC1 is it's infertility. We have made transgenic mice which express the Npcl protein exclusively in fibrillary astrocytes, using the glial fibrillary acidic protein (GFAP) promoter. This selective expression of Npcl corrects sterility in GFAP-Npc1E, Npcl-/- mice. Counts of acidophils in the pituitary of GFAP-Npc1E,Npc1-/-- mice, as compared to Npc1-/- mice, and measurements of dopamine D2 receptor (DRD2) mRNA in the pituitary, suggest mechanisms for fertility enhancement. We conclude that the correction of sterility in GFAP-Npc1E, Npc1-/- mice is a result of restoring hypothalamic control of the pituitary.

Słowa kluczowe

EN

Niemann-Pick type C1 disease; gene expression; NPC1 gene; glial cell; sterility; mice; mouse; steroid synthesis; pituitary gland; neuronal-glial interaction

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 2009
• Tom: 50
• Numer: 4
• Opis fizyczny: p.385-390,fig.,ref.

Twórcy

autor

Donohue C

• Department of Pediatrics, University of Arizona, 1501 N. Campbell Avenue, PO Box 245073, Tucson, AZ 85724-5073, USA

autor

Marion S

• Department of Physiology, University of Arizona, Tucson, Arizona, USA

autor

Erickson R P

• Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA

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