NTPase-helicase of Flaviviridae: inhibitors and inhibition of the enzyme

• Autorzy: Borowski P. , Niebuhr A. , Schmitz H. , Hosmane R.S. , Bretner M. , Siwecka M.A. , Kulikowski T.
• Języki publikacji: EN

Abstrakty

EN

RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of pro­teins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are in­volved in transcription and replication of viral single-stranded RNA genomes. The en­zymatic activities of a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family. The crucial role of the enzyme for the virus life cycle was demonstrated in knock out experiments and by using NTPase/helicase specific inhibitors. This makes the enzyme an attractive tar­get for development of Flaviviridae-specific antiviral therapies. This review will sum-marize our knowledge about the function and structure of the enzyme, update the spectrum of inhibitors of the enzymatic activities of the NTPase/helicase and describe the different mechanisms by which the compounds act. Some of the compounds reviewed herein could show potential utility as antiviral agents against Flaviviridae viruses.

Słowa kluczowe

EN

Flaviviridae; RNA genome; RNA nucleoside triphosphatase; replication; NTPase; enzyme; cell development; inhibition; helicase inhibitor; inhibitor; differentiation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 3
• Opis fizyczny: p.597-614,fig.

Twórcy

autor

Borowski P.

• Bernhard-Nocht-Institut fur Tropenmedizin, 74 Bernhard-Nocht St., 20359 Hamburg, Germany

autor

Niebuhr A.

autor

Schmitz H.

autor

Hosmane R.S.

autor

Bretner M.

autor

Siwecka M.A.

autor

Kulikowski T.

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