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1994 | 40 | 4 |

Tytuł artykułu

CD4 and CD8 cells in mice infected with Trichinella spiralis and treated with cyclosporine A

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EN

Abstrakty

EN
Studies were undertaken to evaluate by parasitological techniques the course of intestinal and muscular invasions in mice infected with Trichinella spiralis and treated with TFX-Thymomodulin (TFX-Th). Studies were conducted on 120 mice of BALB/c and SWISS strains, infected each with a mean invasive dose of 300 T. spiralis larvae. TFX-Th (Thymoorgan GmbH Pharmazie Co. KG, Vienenburg, Germany) was administered subcutaneously at 30 mg/kg body weight. Depending upon duration of TFX-Th administration and stages of intestinal and muscular invasions, three experiments were distinguished in the study. The results indicated that TFX-Th promoted eradication of larvae from muscles, whether administered at the early of the late stage of T. spiralis invasion.

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-

Rocznik

Tom

40

Numer

4

Opis fizyczny

p.357-362,fig.,ref.

Twórcy

autor
  • Polish Academy of Sciences, 50-337 Wroclaw, ul.Norwida 31, Poland
autor
autor
autor

Bibliografia

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  • CAMPBELL W. C., BLAIR L. S. 1978. Combined anthelmintic and corticosteroid therapy of trichinellosis in mice. Trichinellosis, Proceedings of the Fourth International Conference on Trichinellosis. Hannover, New Hampshire [Eds CH. W. KIM and Z. S. PAWŁOWSKI], University Press of New England: 409-417.
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  • -., DĄBROWSKA -BERNSTEIN B., GIEŁDANOWSKI J. 1984. TFX-Polfa, mechanizmy działania i zastosowania terapeutyczne, część kliniczna i farmakologiczna. Poradnik terapeutyczny. Chemil-Warszawa.
  • DENHAM D. A. 1968. Immunity to Trichinella spiralis. III. The longevity of the intestinal phase of infection in mice. J. Helminth. 42: 257-268.
  • DE NOLLIN S., BORGERS M., VANPARIJS O., VAN DEN BOSSCHE H. 1974. Effects of mebendazole on the encysted phase of Trichinella spiralis in the rats: an electron-microscope study. Parasitology 69: 55-62.
  • ELLERT-ŻYGADŁOWSKA J., TROCHA H., LUBAŃSKA-HUBERT E. 1978. Przypadek włośnicy o ciężkim przebiegu z późną eozynofilią we krwi obwodowej. Wiad. Parazytol. 26: 29-32.
  • GABRYEL P., GUSTOWSKA L., BŁOTNA M. 1974. Morphology and histochemistry of muscle in Trichinella-infected rats treated with thiabendazole. Trichinellosis, Proceedings of the Third International Conference on Trichinellosis [Ed. Ctt. W. KIM], Index Educational Publishers, New York: 135-144.
  • -., -., -., KOCIĘCKA W. 1970. Odczyny tkankowe po stosowaniu thiabendazolu w późnej fazie zakażenia włośniem krętym. Pamiętnik V Zjazdu P.T.A.P., Katowice.
  • GERWEL CZ., PAWŁOWSKI Z., KOCIĘCKA W., CHODERA L. 1974. Probable sterilization of Trichinella spiralis by thiabendazole; further clinical observation of human infections Trichinellosis. Trichinellosis, Proceedings of the Third International Conference on Trichinellosis [Ed. CH. W. KIM], Index Educational Publishers, New York: 471-475.
  • GIEŁDANOWSKI J., ŚLOPEK S., KOWALCZYK-BRONISZ S. 1980. Immunobiological and pharmacological properties of Thymus Factor X (fFX). II. Immunotropic activity. Arch. Immunol. Therap. Exp. 28: 853-857.
  • GRENCIS R., BOLAS-FERNANDEZ F., WAKELIN D. 1989. Analysis of cellular immune responses during intestinal infection by Trichinella spiralis in mice treated with Cyclosporin A. Trichinellosis, Proceedings of the Seventh International Conference on Trichinellosis, Alicante, Spain [Ed. CH. E. TANNER]: 165-170.
  • JAMES E. R., DENHAM D. A. 1975. Immunity to Trichinella spiralis. VI. The specificity of immune response stimulated by the intestinal stage. J. Helminthol. 49: 43-47.
  • KARMAŃSKA K., GRABIŃSKI J., PIOTROWSKI R., MICHALSKA Z. 1977. The influence of X-irradiation on immune phenomena in the course of experimental trichinellosis in mice. Wiad. Parazytol. 23: 699-710.
  • -., MICHALSKA Z. 1975. Influence of immunosuppressors (cyclophosphamide and azathioprine) on mast cells in experimental trichinellosis in mice. Ibid. 21: 649-662.
  • -., -. 1977a. Influence of prostaglandin E₂ (PGE₂) on mast cells, histopathological changes and parasites in the course of trichinellosis in mice. Ibid. 23: 725-745.
  • -., -. 1977b. Influence of combined action of histamine and theophylline on mast cells, antibodybearing cells and parasites in the course of experimental trichinellosis in mice. Ibid. 23: 745-755.
  • -., -. 1978. Studies on the mechanism of „self-cure" in trichinellosis. Trichinellosis, Proceedings of the Fourth International Conference on Trichinellosis, Hannover, New Hampshire [Eds CH. W. KIM and Z. S. PAWŁOWSKI], University Press of New England: 207-220.
  • -., -., TOŁPA S., SIDOROWICZ W. 1983. The influence of PT-290 (II) 2 preparation on the organism reactivity in the course of experimental trichinellosis in mice. Wiad. Parazytol. 29: 451-458.
  • KELLY E. A., CRUZ E. S., HAUDA K. M., WASSOM D. L. 1991. IFN-gamma and IL-5 producing cells compartmentalize to different lymphoid organs in Trichinella spiralis infected mice. J. Immunol. 1: 306-311.
  • KLEIN J. S. 1978. Treatment of severe trichinellosis. Trichinellosis, Proceedings of the Fourth International Conference on Trichinellosis, Hannover, New Hampshire [Eds CH. W. KIM and Z. S. PAWŁOWSKI], University Press of New England: 395-406.
  • KOCIĘCKA W. 1971. Behaviour of Trichinella spiralis larvae in animals treated by thiabendazole and hydrocortisone. Wiad. Parazytol. 17: 625-639.
  • -. 1981a. Zależność obrazu klinicznego włośnicy od gatunku lub szczepu włośnia i intensywności inwazji. Część I. Badania kliniczne. Ibid. 27: 399-442.
  • -. 1981 b. Zależność obrazu klinicznego włośnicy od gatunku lub szczepu włośnia i intensywności inwazji. Część II. Badania doświadczalne. Ibid. 27: 443-482.
  • -., GABRYEL P., LESZYK A., GUSTOWSKA L. 1987. A case of fatal trichinellosis with early renal insufficiency and central nervous system involvement. Ibid. 33: 545-551.
  • -., GERWEL C., PAWŁOWSKI Z., KACZMAREK J., STACHOWSKI B., GABRYEL P., GUSTOWSKA L. 1974. Experimental trichinellosis and thiabendazole treatment in Macaca mulatta; clinical and electromyographic observations. Trichinellosis, Proceedings of the Third International Conference on Trichinellosis [Ed. CH. W. KIM], Index Educational Publishers, New York: 123-133.
  • -., RAUHUT W., GUSTOWSKA L. 1989a. The effect of Thymus Factor X (TFX-Polfa) on Trichinella spiralis muscle invasion in mice. Parasitological and histological study. Wiad. Parazytol. 35: 413-421.
  • -., -., IWANOW M. 1991. Intestinal and muscular invasion in mice infected with Trichinella spiralis and treated with TFX-Thymomodulin. 17th International Congress of Chemotheraphy, Berlin, FRG, June 23-28, 1991, Poster session 158: 1536.
  • -., SKRZYPIŃSKA K., MACHOWSKA L. 1989b. The effect of Thymus Factor X (TFX-Polfa) on the clinical course of human trichinellosis. Wiad. Parazytol. 35: 423-433.
  • -., STEFANIAK J., KACPRZAK E., PAKUŁA M. 1989c. Clinical evaluation of albendazole in the therapy of human trichinellosis. Ibid. 35: 457-466.
  • KOZAR Z., KOZAR M. 1963. The course of experimental trichinellosis in mice. Methods of infection and the influence of various invasive doses on the mortality and weight of the animals. Ibid. 9: 403-418.
  • -., -. 1966/ 67. Experimental studies in mice on the therapy of trichinellosis (thiabendazol, neguvon, cortisone, azulen, sera). Acta Parasitol. Polon. 14: 133-161.
  • LARSH J. E., Jr 1963. Experimental trichiniasis. Advances in Parasitology. I. Acad Press, London, New York.
  • LJUNGSTRÖM I., FERRANTE A. 1984. The in vitro and in vivo immunodepression by Trichinella spiralis, a preliminary report. Trichinellosis, Proceedings of the Sixth International Conference on Trichinellosis. Far Hills Inn, Val Morin, Quebec, Canada [Ed. CH. W. KIM], Albany, New York, The State University of New York Press: 63-68.
  • LUFT B. J., KIM C. W. 1988. T-cell dysfunction during acute murine trichinellosis. Trichinellosis, Proceedings of the Seventh International Conference on Trichinellosis, Alicante, Spain [Ed. CH. E. TANNER]: 153-158.
  • ŁAPSZEWICZ A., PAWŁOWSKI Z., GABRYEL P. 1969. Thiabendazole in human trichinellosis. Wiad. Parazytol. 15: 759-760.
  • MACHNICKA B., GOLIŃSKA Z., BANY J. 1979. The influence of cyclophosphamide on immunity in mice infected with Trichinella spiralis. Ibid. 25: 505-517.
  • OZERECKOVSKAJA N. N. 1965. Vlianie steridnoi terapii na osryj period trichinelloza i na period rekonvalescencii. Soobščenie I. Vlianie steroidnoi terapii na prodolžitelnost' perioda otiekov, lichoradki, mialgii i obščuju dlitelnost' zabolevania. Med. Parazitol. Paraz. Bol. 34: 379-387.
  • -., POTEKAEVA M. A., TUMOLSKAJA N. J., MARGULIS T. D., VIŠNEVSKIJ V. A. 1966. Vlianie steroidnoi terapii na ostryj period rekonvalescencii. Soobščenie II. Vlianie steroidov na kliniku i morfologiu myšečnych poraženii pri trichinelloze. Ibid. 35: 164-171.
  • OZERETSKOVSKAYA N. N., TUMOLSKAYA N. I., PEREVERZEVA E. V., BRONSHTEIN A. M., MORENEZ T. M., LMMAMBULEV K. D. 1978. Benzimidazoles in the treatment and prophylaxis of synanthropic and sylvatic trichinellosis. Trichinellosis, Proceedings of the Fourth International Conference on Trichinellosis, Hannover, New Hampshire (Eds CH. W. KIM and Z. S. PAWŁOWSKI], University Press of New England : 381-393.
  • PAWŁOWSKI Z. 1967. Adrenal cortex hormones in intestinal trichinellosis. I. Effect of adrenalectomy, desoxycorticosterone and glucocorticoids on the course of trichinellosis in rats. Acta Parasitol. Polon. 15: 157-170.
  • PEREVERZEVA E. V. 1979. Osobennosti rozvitia myšečnych ličinok trichinell ot burogo medvedja i effekt mebendazola u belych myšej. Med. Parazitol. Paraz. Bol. 5: 40-43.
  • -., OZERETSKOVSKAYA N. N., VERETENNIKOVA N. L. 1978. Efficacy of carbamate benzimidazole derivatives and morphological changes in parasite and host muscle tissue in experimental trichinellosis. Trichinellosis, Proceedings of the Fourth International Conference on Trichinellosis, Hannover, New Hampshire [Eds CH. W. KIM and Z. S. PAWŁOWSKI], University Press of New England: 419-436.
  • PODHÁJECKÝ K. 1962. Localization of intestinal Trichinellae in the small intestine of mice in their intestinal phase. Wiad. Parazytol. 8: 633-636.
  • RUITENBERG E. J., BUYS J. 1986. Eosinophils and mononuclear cells as effector cells in a Trichinella spiralis infection; cell biological and biochemical aspects and the use of biological Response modifiers. Ibid. 32: 219-231.
  • -., ELGERSMA A., KRUIZING W., LEENSTRA F. 1978. Host protection to the intestinal phase of Trichinella spiralis. Trichinellosis, Proceedings of the Fourth International Conference on Trichinellosis, Hannover, New Hampshire [Eds CH. W. KIM and Z. S. PAWŁOWSKI], University Press of New England: 169-181.
  • ŚLOPEK S., GIEŁDANOWSKI J., KOWALCZYK-BRONISZ S. 1980. Immunobiological and pharmacological properties of Thymus Factor X (TFX). I. Biological and pharmacological activity. Arch. Immunol. Therap. Exp. 28: 827-851.
  • TEPPEMA J. S., BLAMJOUS F. J. E. M., ELGERSMA A., RUITENBERG E. J. 1981. Trichinella pseudospiralis and T. spiralis infections in monkeys. III. Pathological aspects. Trichinellosis, Proceedings of the Fifth International Conference on Trichinellosis, Noordwijk aan Zee, The Netherlands (Eds CH. W. KIM, J. RUJTENBERG and J. S. TEPPEMA], Surrey, England. Redbook
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  • THIENPONT D., VANPARIJS O. F., VANDESTEENE R. 1974. Anthelmintic and histopathological effect of mebendazole on Trichinella spiralis in the rat. Trichinellosis, Proceedings of the Third International Conference on Trichinellosis [Ed. CH. W. KIM], Index Education Publisheres, New York: 515-527.

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Bibliografia

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