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1999 | 46 | 2 |

Tytuł artykułu

Carbohydrate moiety of immunoglobulins in health and pathology

Autorzy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Most of glycoproteins described so far, including immunoglobulins, are glycosylated during post-translational modifications of protein molecules. Current knowledge of the structure of sugar chains in immunoglobulin molecules and their biological role in health and pathology is reviewed.

Wydawca

-

Rocznik

Tom

46

Numer

2

Opis fizyczny

p.341-350

Twórcy

  • Polish Academy of Sciences, R.Weigla 12, 53-114 Wroclaw, Poland, e-mail: krotkiew@immuno.iitd.pan.wroc.pl

Bibliografia

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  • 3. Youings, A., Chang, S.-C., Dwek, R.A. & Scragg, I.G. (1996) Site-specific glycosylation of human immunoglobulin G is altered in four rheumatoid arthritis patients. Biochem. J. 314, 621-630.
  • 4. Borel, I.M., Gentile, T., Angelucci, J., Margni, R.A. & Binaghi, R.A. (1989) Asymmetrically glycosylated IgG isolated from non-immune human sera. Biochim. Biophys. Acta 990, 162-164.
  • 5. Grabenau, R.C., Goldenberg, D.M., Chang, C.- H., Koch, G.A., Gold, D.V., Kunz, A. & Han­sen, H.J. (1992) Microheterogeneity of a puri- fled IgGl due to asymmetric Fab glycosyla- tion. Mol Immunol. 29, 751-758.
  • 6. Spiegelberg, H.L., Abel, C.A., Fishkin, B.G. & Grey, H.M. (1970) Localization of the carbohy­drate within the variable region of light and heavy chains of human yG myeloma proteins. Biochemistry 9. 4217-4222.
  • 7. Kabat, E.A., Wu, T.T., Perry, H.M., Gottes- man, K.S. & Foeller, C. (1991) Sequences of Proteins of Immunological Interest, vol. 1, 5th U.S. edn., Department of Health and Human Services, Washington.
  • 8. Rothman, R.J., Warren, L., Vliegenthart, J.F.G. & Hard, K.J. (1989) Clonal analysis of the glycosylation of immunoglobulin G se­creted by murine hybridomas. Biochemistry 28. 1377-1384.
  • 9. Krotkiewski, H., Gronberg, G., Krotkiewska, B., Nilsson, B. & Svensson, S. (1990) The car­bohydrate structures of a mouse monoclonal IgG antibody OKT3. J. Biol Chem. 265, 20195-20201.
  • 10. Patel, T.P., Parekh, R.B., MoeUering, B.J. & Prior, C.P. (1992) Different culture methods lead to differences in glycosylation of a murine IgG monoclonal antibody. Biochem. J. 285, 839-845.
  • 11. Taniguchi, T., Mizuochi, T., Beale, M., Dwek, R.A., Rademacher, T.W. & Kobata, A. (1985) Structures of the sugar chains of rabbit immu­noglobulin G: Occurrence of asparagine- linked sugar chains in Fab fragment Biochem­istry 24, 5551-5557.
  • 12. Aoki, N., Furukawa, K., Iwatsuki, K., Noda, A., Sato, T., Nakamura, R. & Matsuda, T. (1995) A bovine IgG heavy chain contains N- acetylgalactosaminylated N-linked sugar chains. Biochem. Biophys. Res. Commun. 210, 275-280.
  • 13. Kim, H.-H., Yamaguchi, Y., Masuda, K., Mat- sunaga, C., Yamamoto, K., Irimura, T., Taka- hashi, N.f Kato, K. & Arata, Y. (1994) O- glycosylation in hinge region of mouse immu­noglobulin G2b. J. Biol Chem. 269, 12345- 12350.
  • 14.Shimizu, A., Putnam. F.W. & Paul. C. (1971) Structure and role of the five glycopeptides of human IgM immunoglobulins. Nature New Bi­ology 231, 73-76.
  • 15. Anderson, D.R., Atkinson, P.H. & Grimes, W.J. (1985) Major carbohydrate structures at five glycosylation sites on murine IgM deter­mined by high resolution JH-NMR spectros­copy. Arch. Biochem. Biophys. 243,605-618.
  • 16. Krotkiewski, H., Nilsson, B. & Svensson, S. (1989) Structural analysis of the carbohydrate chains of a mouse monoclonal IgM antibody. Eur. J. Biochem. 184, 29-38.
  • 17. Mattu, T.S., Pleass, R.J., Willis, A.C., Kilian, M., Wormald, M.R., Lellouch, A.C., Rudd, P.M., Woof, J.M. & Dwek, R.A. (1998) The gly­cosylation and structure of human serum IgAl, Fab, and Fc regions and the role of N- glycosylation on Fc« receptor interactions. J. Biol. Chem. 273, 2260-2272.
  • 18. Lipniunas, P., Gronberg, G., Krotkiewski, H., Angel, A.-S. & Nilsson, B. (1993) Investigation of the structural heterogeneity in the carbohy­drate portion of a mouse monoclonal immuno­globulin A antibody. Arch. Biochem. Biophys. 300, 335-345.
  • 19. Rousseaux-Prevost, R., Coddeville, B., Spik, G., Wieruszeski, J.M., Strecker, G. & Mon- treuil, J. (1987) The carbohydrate structure of the N-linked oligosaccharides of rat mono­clonal IgE; in Glycoconjugates, Proceedings of the IX International Symposium, Lille, France, 6-11 July, Abstract A101.
  • 20. Donadel, G., Calabro, A., Sigounas, G., Has- call, V.C., Notkins, A.L. & Harindranath, N. (1994) Human polyreactive and monoreactive antibodies: Effect of glycosylation on antigen binding. Glycobiology 4, 491-496.
  • 21. Taylor, A.K. & Wall, R. (1988) Selective re­moval of a heavy-chain glycosylation sites causes immunoglobulin A degradation and re­duced secretion. Mol Cell Biol. 8, 4197- 4203.
  • 22. Wawrzynczak, E.J., Cumber, A.,J., Parnell, G.D., Jones, P.T. & Winter, G. (1992) Blood clearance ir. the rat of a recombinant mouse monoclonal antibody lacking the N-linked oli­gosaccharide side chains of the Ch2 domains. Mol Immunol 29. 213-220.
  • 23. Endo, T., Wright, A., Morrison, S.L. & Ko- bata, A. (1995) Glycosylation of the variable region of immunoglobulin G — site specific maturation of the sugar chains. Mol Immu­nol. 32, 931-940.
  • 24. Ey, P.L., Prowse, S.J. & Jenkin, C.R. (1978) Isolation of pure IgGl, lgG2a and IgG2b im­munoglobulins from mouse serum using pro­tein A-Sepharose. Immunochemistry 15, 429- 436.
  • 25. Wallick, S.C., Kabat, E. & Morrison, S.L. (1988) Glycosylation of a Vjj residue of a monoclonal antibody against a(l-6) dextran increases its affinity for antigen. J. Exp. Med. 168, 1099-1109.
  • 26. Wright, A., Tao, M., Kabat, E.A. & Morrison, S.L. (1991) Antibody variable region glycosy­lation: Position effects on antigen binding and carbohydrate structure. EMBO J. 10, 2717- 2723.
  • 27. Co, M.S., Scheinberg, D.A., Avdalovic, N.M., McGraw, K., Vasquez, M., Caron, P.C. & Queen, C. (1993) Genetically engineered de- glycosylation of the variable domain increases the affinity of an anti-CD33 monoclonal anti­body. Mol Immunol 30, 1361-1367.
  • 28. Kobata, A. (1998) A retrospective and pro­spective view of glycopathology. Glycoconju- gate J. 15, 323-331.
  • 29. Hakomori, S-i. (1991) Possible functions of tumor-associated carbohydrate antigens. Curr. Opin. Immunol 3, 646-653.
  • 30. Lisowska, E. (1995) Tn antigens and their sig­nificance in oncology. Acta Biochim. Polon. 42. 11-18.
  • 31. Klopocki, A.G., Laskowska, A., Antoniewicz- Papis, J., Duk, M., Lisowska, E. & Ugorski, M. (1998) Role of sialosyl Lewis8 in adhesion of colon cancer cells. The antisense RNA ap­proach. Eur. J. Biochem. 253, 309-318.
  • 32. Tsuchiya, N., Endo, T., Matsuta, K., Yoshi- noya, S., Takeuchi, F., Nagano, Y., Shiota, M., Furukawa, K., Kochibe, N., Ito, K. & Kobata, A. (1993) Detection of glycosylation abnormal­ity in rheumatoid IgG using 7V-acetylgluco- samine-specific Psathyrella velutina lectin. J. Immunol 151, 1137-1146.
  • 33. Tsuchiya, N., Endo, T., Shiota, M., Kochibe, N., Ito, K. & Kobata, A. (1994) Distribution of glycosylation abnormality among serum IgG subclasses from patients with rheumatoid ar­thritis. Clin. Immunol Immunopathol 70, 47-50.
  • 34. Routier, F.H., Hounsell, E.F., Rudd, P.M., Takahashi, N., Bond, A., Hay, F.C., Alavi, A., Axford, J.S. & Jefferis, R. (1998) Quantitation of the oligosaccharides of human serum IgG from patients with rheumatoid arthritis: A critical evaluation of different methods. J. Im­munol Methods 213, 113-130.
  • 35. Malhotra, R., Wormald, M.R., Rudd, P.M., Fischer, P.B., Dwek, R.A. & Sim, R.B. (1995) Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nature Medi­cine 1, 237-243.
  • 36. Griffiths, H.R. & Lunec, J. (1989) The effects of oxygen free radicals on the carbohydrate moiety of IgG. FEBS Lett. 245, 95-99.
  • 37. Kondo, A., Hosokawa, Y., Kiso, M., Hase- gawa, A. & Kato, I. (1994) Analysis of oligosac­charides of human IgG from serum of leuke­mia patients. Biochem. Mol Biol Int 32, 897-902.
  • 38. Jaeken, J., Carchon, H. & Stibler, H. (1993) The carbohydrate-deficient glycoprotein syn­dromes: Pre-Golgi and Golgi disorders? Glyco- biology 3, 423-428.
  • 39. Gu, J., Kondo, A., Okamoto, N. & Wada, Y. (1994) Oligosaccharide structures of immuno­globulin G from two patients with carbo­hydrate-deficient glycoprotein syndrome. Gly­cosylate & Disease 1. 247-252.
  • 40. Yamashita, K., Ideo, H., Ohkura, T., Fu- kushima, K., Yuasa, I., Ohno, K. & Takeshita, K. (1993) Sugar chains of serum transferrin from patients with carbohydrate deficient gly­coprotein syndrome.
  • 41.Dwek, R.A. (1996) Glycobiology: Toward un­derstanding the function of sugars. Chem. Rev. 96, 683-720.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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