Flash visual evoked potentials [FVEP] in newborn rats after pre- and postnatal exposure to zinc

• Autorzy: Herba E , Pojda-Wilczek D. , Pojda S.M. , Makowiecka-Obidzinska K. , Plech A.R. , Szkilnik R. , Brus R.
• Języki publikacji: EN

Abstrakty

EN

The aim of this paper was to find any alterations in flash visual evoked potentials (FVEP) after pre- and postnatal exposure to Zn in rats. 18 white adult Wistar rats drank tap water containing 50ppm of ZnSO₄ x 7H₂O and ate pelleted food during 21 days of pregnancy. 14 pregnant rats of the control group drank only tap water. 10 newborn rats from pure (without prenatal Zn exposure) breeding had the oral Zn supplementation with the same dose of Zn for 21 postnatal days. The fluid consumption of each dam and each offspring rat was monitored daily. Every rat during the whole period consumed about 66.15mg of pure Zn. The offsprings were divided into three groups: prenatal Zn group (18 rats), postnatal Zn group (10 rats) and control group (14 rats). The FVEP recordings were made using the UTAS 1000 LKC electrophysiologically interfaced personal computer system (USA), with Ganzfield stimulation in all groups every 5 min for 30 min. The decrease in the latencies and increase in the amplitudes of N₁ and P₁ waves were observed in both Zn groups in comparison to the control, but only in the prenatal Zn group were the changes statistically significant. The maternal Zn supplementation may have a beneficial influence on visual cortical responses in newborn rats.

Słowa kluczowe

EN

flash visual evoked potential; prenatal exposure; newborn rat; zinc; rat; postnatal expossure

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2007
• Tom: 16
• Numer: 1
• Opis fizyczny: p.63-66,fig.,ref.

Twórcy

autor

Herba E

• Silesian Medical University, Katowice, Poland

autor

Pojda-Wilczek D.

autor

Pojda S.M.

autor

Makowiecka-Obidzinska K.

autor

Plech A.R.

autor

Szkilnik R.

autor

Brus R.

Bibliografia

• 1. GRAHN B.H., PATERSON P.G., GOTTSCHALL-PASS K.T., ZHANG Z. Zinc and the eye. J Am Coll Nutr. 20 (2 Suppl), 106, 2001.
• 2. MICELI M.V., TATE D.J.JR., ALCOCK N.W., NEWSOME D.A. Zinc deficiency and oxidative stress in the retina of pigment rats. Invest Ophthalmol Vis Sci. 40 (6), 1238, 1999.
• 3. LEURE-DUPREE A.E., MCCLAIN C.J. Changes in retinal morphology and vitamin A metabolism as a consequence of decreased zinc availability. Retina. 2, 294, 1982.
• 4. HYUN H.J., SOHN J.H., HAD.W., AHN Y.H., KOH J.Y., YOON Y.H. Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 42 (2), 460, 2001.
• 5. HYUN H.J., SOHN J.H., AHN Y.H., SHIN H.C., KOH J.Y., YOON Y.H. Depletion of intracellular zinc induces macromolecule synthesis- and caspase -dependent apoptosis of cultured retinal cells. Brain Res. 869 (1-2), 39, 2000.
• 6. JAMPOL L.M. et al: Age-related eye disease study research group (collective name-ARED S). A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta-carotene and zinc for age-related macular degeneration and vision loss: AREDS report no.8. Arch Ophthalmol. 119, 1417, 2001.
• 7. TATE D.J., NEWSOME D.A., OLIVER P.D. Metallothionein shows an age-related decrease in human macular retinal pigment epithelium. Invest Ophthalmol Vis Sci. 34 (7), 2348, 1993.
• 8. FREDERICKSON C.J., SUH S.W., SILVA D., FREDERICKSON C.J., THOMPSON R.B. Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr. 130 (5S Suppl), 1471S, 2000.
• 9. TAKEDA A., TAKEFUTA S., OKADA S., OKU N. Relationships between brain zinc and transient learning impairment of adults rats fed zinc-deficient diet. Brain Res. 859 (2), 352, 2000.
• 10. WALLWORK J.C. Zinc and the central nervous system. Prog Food Nutr Sci. 11 (2), 203, 1987.
• 11. HERBA E: The effect of prenatal exposure to cadmium on flash visual evoked potentials in rats. Pol J Envir Stud. 8 (Suppl II ), 167, 1999.
• 12. HERBA E., POJDA -WILCZEK D., PLECH A.R., POJDA S.M., SZKILNIK R. Influence of dopamine on flash visual evoked potentials (FVEP) in prenatally mercury intoxicated rats. Pol J Pharmacol. 56, 415, 2004.
• 13. POJDA S.M., PLECH A.R., POJDA -WILCZEK D., HERBA E., SZKILNIK R. Visual evoked cortical potential in prenatal mercury intoxicated rats. Pol J Envir Stud. 8 (Suppl II ), 170, 1999.
• 14. POJDA S.M., POJDA D. Pattern Visual Evoked Responses in amblyopic and cured children. 18th meeting European Strabismological Association, Kraków, pp. 401, 1989. [In Polish]
• 15. CHIAPPA K. H., ROPPER A.H. Evoked potentials in clinical medicine. N Engl J Med. 306, 1140, 1982.
• 16. HOLLIDAY A.M. The visual evoked potential in healthy subjects. In: Evoked Potentials in Clinical Testing. (ed) Churchill Livingstone, Edinburgh, London, Madrid, Melbourne, New York, Tokio, pp 53-113, 1993.
• 17. PATERSON P.G., GRAHN B.H., GOTTSCHALL-PASS K.T., GORECKI D.K.J., SEMPLE H.A. Postnatal deficiencies of zinc and taurine alter electroretinograms, oscillatory potentials and morphology of the rat retina. Nutr Neurosci. 2, 175, 1999.
• 18. LABUS L., SZKILNIK R., NOWAK P., BIELACZYC G., BRUS R. The influence of Zn exposure during the intrauterine and early postnatal time on the behaviour of adult rats. Metabolism of Drugs and Xenobiotics. The Conference of Polish Toxicology Society. Programme and Abstracts, pp. 36-37, 2004. [In Polish]
• 19. NOWAK P., LABUS L., KONECKI J., GŁOWACKA M., ZAGZIŁ T., SZKILNIK R., BIELACZYC G. et al. The contents of biogenic amin and the 3H glucose uptake in the brain of the mature rats after pre and postnatal exposure to Zn. The Conference of Polish Toxicology Society. Programme and Abstracts, pp. 35-36, 2004. [In Polish]
• 20. ARNOLD L.E., PINKHAM S.M., VOTOLATO N. Does zinc moderate essential fatty acid and amphetamine treatment of attention-deficit/ hyperactivity disorder? J Child Adolesc Psychopharmacol. 10 (2), 111, 2000.
• 21. COLVIN R.A., DAVIS N., NIPPER W., CARTER A.C. Zinc transport in the brain: Routes of Zinc influx and efflux in neurons. J Nutr. 130 (5), 1484S, 2000.
• 22. CHOWANADISAI W., KELLEHER S.L., LONNERDA L B. Maternal zinc deficiency reduces NMDA receptor expression in neonatal rat brain, which persists into early adulthood. J Neurochem. 94 (2), 510, 2005