Characterization of a novel transcript variant of human STAU1 gene

• Autorzy: Nie F. , Yao H. , Qi R. , Li X. , Wu C.
• Języki publikacji: EN

Abstrakty

EN

Human STAU1 is one member of the family of double-stranded RNA (dsRNA)-binding proteins. It is thought to function in transporting mRNA, controlling translation and eliciting mRNA decay in neurons, and to function in infection of influenza virus and human immunodeficiency virus type 1 (HIV-1). Four transcripts coding two isoforms have been identified before. In this study, we have isolated a novel transcript of STAU1, coding a novel isoform that has six amino acids more (SFPLKQ) than isoform a. In order to examine the tissue distribution of this novel isoform, we have performed RT-PCR experiments and the analysis showed that it was highly expressed in heart, liver, kidney and pancreas.

Słowa kluczowe

EN

RNA binding protein; RNA localization; gene; human STAU1 gene; novel variant; neuron; infection; influenza virus; human immunodeficiency virus; isoform; novel isoform; tissue distribution; heart; liver; kidney; pancreas

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2008
• Tom: 55
• Numer: 3
• Opis fizyczny: p.473-478,fig.,ref.

Twórcy

autor

Nie F.

• Tongji University, Shanghai, PR China

autor

Yao H.

autor

Qi R.

autor

Li X.

autor

Wu C.

Bibliografia

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