Behavioural effects of luteinizing hormone-releasing hormone [LHRH] in rats

• Autorzy: Mrowiec J , Plech A. , Rzeszotarska B. , Ryszka F. , Brus R. , Masiukiewicz E.
• Języki publikacji: EN

Abstrakty

EN

Behavioural effects of intracerebroventricularly-injected (icv) LHRH were studied in female rats. Locomotor and exploratory activities as well as irritability were determined. A pronounced inhibitory effect of 10µg doses of LHRH was found. At 100/µg doses of LHRH, barrel behaviour was observed. We conclude that LHRH can modify the activity of central serotonergic receptors in rats.

Słowa kluczowe

EN

behaviour; behavioural effect; releasing hormone; exploratory activity; luteinizing hormone; gonadotrophin; rat; irritability; locomotion

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1992
• Tom: 43
• Numer: 3
• Opis fizyczny: p.271-278,fig.

Twórcy

autor

Mrowiec J

• Silesian Medical Academy of Katowice, K.Marksa Str. 38, 41-808 Zabrze, Poland

autor

Plech A.

autor

Rzeszotarska B.

autor

Ryszka F.

autor

Brus R.

autor

Masiukiewicz E.

Bibliografia

• 1. Silverman AJ. The gonadotropin-releasing hormone (GnRH) neuronal systems: Immunocytochemistry. In: The Physiology of Reproduction, E Knobil, I Heill (eds). New York, Raven Press, 1988, Chapter 29.
• 2. Krey LC, Silverman AJ. Luteinizing hormone releasing hormone. In: Brain Peptides, PT Krieger, M Browstein, J Martin (eds). New York, Wiley, 1987, p. 687-709.
• 3. King JC, Tobet SA, Snaely FL, Arimura AA. LH-RH immunopositive cells and their projections to the median eminence and organum vasculosum of the lamina terminalis. J Comp Neurol 1982; 209: 287-300.
• 4. Merchenthaler I, Kovacs G, Lovasz G, Setalo G. The preopticoinfundibular LH-RH tract in the rat. Brain Res 1980; 198: 63-74.
• 5. Leblanc P, Crumeyrolle M, Latrouche J, et al. Characterization and Distribution of Receptors for Gonadotropin-Releasing Hofmone in the Rat Hippocampus. Neuroendocrinology 1988; 48: 482-488.
• 6. Schwanzel-Fukuda M, Pfaff DW. Origin of luteinizing hormone-releasing hormone neurons. Nature 1989; 338: 161-164.
• 7. Moss RL, McCann SM. Induction of mating behavior in rats by luteinizing hormone-releasing hormone. Science 1973; 181: 177-179.
• 8. Pfaff DW. Luteinizing hormone-releasing factor potentiates lordosis behavior in hypophysec- tomized ovariectomized female rats. Science 1973; 182: 1148-1149.
• 9. Know LM, Pfaff DW. Behavioral effects of neuropeptides: some conceptual consideration. In: Peptide hormones: effects and mechanisms of action, A Negro-Vilar, PM Conn (eds). vol. I, Boca Raton, CRC Press, 1988, pp. 141-164.
• 10. Dudley CA, Moss LR. Brain Res 1988; 441: 161-167.
• 11. Nasello AG, Bydlowski CR, Felicio LF. The Effect of LHRH on Rat Conditioned Avoidance Behavior: Interaction with Brain Cetecholamines. Pharmac Biochem Behav 1990; 37: 639-642.
• 12. Telegdy D, Fekete M. Värszegi M, Kádár T. Effect of peptide hormones on biogenic amines of the central nervous system. In: Advances in Pharmacological Research and Practice Gen, Knoll J (ed). vol. VII, Aminergic and Peptidergic Receptors, ES Vizi, M Wolleman (eds). Budapest, Pergamon Press, Akademiai Kiadó, 1980, pp. 169 -185.
• 13. Karten MJ, Hook WA, Siraganian RP, Coy DH, Folkers K, Rivier J. E, Roeske RW. In vitro histamine realese with LHRH analogs. In: LHRH and Its Analogs, JJ Nestor Jr, BH Vickery (eds). Lancaster, MPT, 1987, pp. 179-190.
• 14. James MD, Kac Kenzie FJ, Tuochy-Jones PA, Wilson CA. Dopamin-ergic Neurones in the Zona Incerta Exert a Stimulatory Control on Godadotrophin Release via Dx Dopamine Receptors. Neuroendocrinology 1987; 45: 348-355.
• 15. Mrowiec J. Ośrodkowe efekty farmakologiczne gonadoliberyny i jej analogu leuprolidu u szczurów. D. thesis, Śląska Akademia Medyczna Zabrze 1990.
• 16. Mrowiec J, Felińska W, Szkilnik R, et al. Wpływ gonadoliberyny (LHRH) na zawartość amin biogennych w częściach mózgu samic szczurzych. Annales Acad Med Silesiensis 1992; in press.
• 17. Dixon AK, Hill RC, Roemer D, Scholtysik G. Pharmacological Properties of 4- (l-Methyl-4-piperidylidene)-9, 10-dihydro-4H-benzo-4.5-cyclohepta-l, 2-thiophene Hydrogen Maleate (Pizotifen). Arzneimittel Forsch 1977; 27: 1968-1979.
• 18. Przegaliński E, Baran L, Palider W, Siwanowicz J. The central action of' pizotifen. Psychopharmacology 1979; 62: 295-300.
• 19. Mrowiec J, Juraszczyk Z, Neuman U, et al Behavioral effects of gonadoliberin (LHRH) in rats. In: X Congress of the Polish Pharmacological Society, September 6-9, 1989, Bialystok. Abstracts p. 110.
• 20. Herman ZS. The effect of noradrenaline on rat’s behaviour. Psychopharmacology 1970; 16: 369-374.
• 21. Masiukiewicz E, Rzeszotarska B. Large-Scale Synthesis of Mammalian Gonadoliberin without Protection of Side-Chain Functions. J Prakt Chem 1991; 333: 41-47.
• 22. Janssen PA, Jageneau AHM, Schellekens KHL. Chemistry and pharmacology of compounds related to 4- (4-hydroxy)-4-phenylpiper-idino-butyrophenone. Part IV. Influence of haloperidol (R 1025) and chlorpromazine on the behavior of rat in unfamiliar “open field” situation. Psychopharmacology 1960; 1: 389-392.
• 23. File SE. Effects of chlorpromazine on exploration and habituation in the rat. Br J Pharmacol Chemother 1973; 49: 303-310.
• 24. File SE, Pope JH. The action of chlorpromazine on exploration in pairs of rats. Psychopharmacology 1974; 37: 249-254.
• 25. Nakamura K, Thoenen H. Hypothermia induced by intraventricular administration of 6-hydroxydopamine in rats. Eur J Pharmacol 1971; 16: 46-53.
• 26. Wolny HL, Herman ZS. Zachowanie się szczurów w różnych fazach cyklu płciowego. Endokrynologia Polska 1974; 25: 335-340.
• 27. Fink G. Gonadotropin Secretion and Its Control. In: The Physiology of Reproduction, E Knobil, J Neill (eds). New York, Raven Press, 1988. pp. 1349-1377.
• 28. Katz RJ. Behavioral effects of dynorphin, a novel opioid neuropeptide. Neuropharmacology 1980; 19: 801-802.
• 29. Herman ZS, Stachura Z, Opiełka Ł, Siemion IZ, Nawrocka E. Tuftsin and D-Arg³- tuftsin possess analgesic action. Experientia 1981; 37: 76-77.
• 30. De Wied D, Gaffori О, Van Ree JM, De Jong W. Vasopressin antagonists block peripheral as well as central vasopressin receptors. Pharmac Biochem Behav 1984; 21: 393-400.