Active synthesis of epidermal growth factor in human mammary glands

• Autorzy: Walczak M. , Pawlus B. , Kedzia A. , Walkowiak J.

Warianty tytułu

PL

Synteza nablonkowego czynnika wzrostu w mleku ludzkim

• Języki publikacji: EN

Abstrakty

EN

Background. Human milk contains considerable number of growth factors, including epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1). There are no data comparing the EGF and IGF-1 levels in the serum and milk of breast-feeding women. Therefore, the aim of our study was to assess a possible relationship between the concentrations of these growth factors. Material and methods. Thirty-nine women in child-birth were included in the study. Ali women provided blood and milk samples during the first six hours after delivery. EGF (by immunoenzymatic method) and IGF-1 (by radioimmunossay method) concentrations were measured in both media. Results. EGF breast milk concentrations ranged from 3.18 to 4.51 ng/ml and on average were significantly higher (p < 0.0001) than those found in the women’s serum (front 0.02 to 0.13 ng/ml). The opposite distribution was found for IGF-1 levels. Its milk concentrations ranged from 8.8 to 61.9 ng/ml and on average were significantly lower (p < 0.0001) than the serum concentrations (from 192.6 to 595.3 ng/ml). No correlation was found between the serum and milk concentrations of both growth factors. Conclusion. EGF seems to be synthesized locally in mammary glands, whereas IGF-1 probably permeates into the milk from the vascular bed.

PL

Wstęp. Ludzkie mleko zawiera znaczącą liczbę czynników wzrostowych, w tym nabłonkowy czynnik wzrostu (epidermal growth factor - EGF) oraz insulinopodobny czynnik wzrostu (insulin-like growth factor-1 - IGF-1). Dotychczas nie porównano poziomów EGF i IGF-1 w surowicy i mleku karmiących kobiet. Dlatego też celem badania była ocena potencjalnego związku pomiędzy stężeniami tych czynników wzrostowych. Materiał i metody. Badaniami objęto 39 rodzących kobiet, u których próbki krwi oraz mleka pobrano w okresie 6 godzin od porodu. W obydwu mediach oceniono stężenia EGF (metoda immunoenzymatyczna) i IGF-1 (metoda radioimmunoenzymatyczna). Wyniki. Stężenia EGF w mleku kobiecym wynosiły od 3,18 do 4,51 ng/ml i były znacząco większe (p < 0,0001) niż w surowicy (od 0,02 do 0,13 ng/ml). Odwrotny rozkład wartości stwierdzono dla IGF-1, stężenia czynnika wzrostowego w mleku wynosiły od 8,8 do 61,9 ng/ml i były znacząco mniejsze (p < 0,0001) niż w surowicy (od 192,6 do 595,3 ng/ml). Nie wykazano występowania żadnych zależności pomiędzy stężeniami badanych czynników wzrostowych w mleku i surowicy. Wnioski. Wydaje się, że EGF jest syntetyzowane miejscowo w gruczołach mlecznych, natomiast IGF-1 najprawdopodobniej przechodzi do mleka z łożyska naczyniowego.

• Wydawca: -
• Czasopismo: Acta Scientiarum Polonorum. Technologia Alimentaria
• Rocznik: 2010
• Tom: 09
• Numer: 2
• Opis fizyczny: p.237-241,ref.

Twórcy

autor

Walczak M.

• Pomeranian Medical Univesity in Szczecin, Szczecin, Poland

autor

Pawlus B.

autor

Kedzia A.

autor

Walkowiak J.

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