New carbocyclic analogues of netropsin: synthesis and inhibition of topoisomerases

• Autorzy: Puckowska A. , Bielawski K. , Bielawska A. , Rozanski A.
• Języki publikacji: EN

Abstrakty

EN

A series of carbocyclic analogues of netropsin were synthesized and evaluated for their capacity to inhibit human topoisomerases I and II in vitro. The compounds are oligopeptides containing 1,4-di- and 1,2,5-trisubstituted benzene rings and unsubstituted N-terminal NH2 groups. Compounds 4-7 consist of two netropsin-like units linked by aliphatic (tetra- and hexamethylene) chains. In the topoisomerase I and II assay, the relaxation of pBR322 plasmid was inhibited by compounds 4-7 at 100 uM concentration.

Słowa kluczowe

EN

man; lexitropsin; DNA modification; DNA interaction; netropsin; oligopeptide; topoisomerase; carbocyclic analogue

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 1
• Opis fizyczny: p.177-183,fig.

Twórcy

autor

Puckowska A.

• Medical Academy of Bialystok, A.Mickiewicza 2c, 15-230 Bialystok, Poland

autor

Bielawski K.

autor

Bielawska A.

autor

Rozanski A.

Bibliografia

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