A moderate dose of cycloheximide does not prevent the febrile response to endotoxin but interfere with induction of pyrogenic tolerance in rabbit

• Autorzy: Kozak W , Soszynski D. , Wachulec M. , Szewczenko M. , Bodurka M.
• Języki publikacji: EN

Abstrakty

EN

The purpose of the present study was to examine the effect of cycloheximide (Cx) - inhibitor of protein synthesis, on the development of pyrogenic tolerance to LPS. It has been observed that Cx at a dose of 1 mg/kg given intravenously 1 h prior to LPS did not prevent fever response, however it modified the induction of pyrogenic tolerance. It was manifested in existence of the second phase of fever after the following administrations of LPS into rabbits pretreated with Cx. In control group of rabbits the induction of pyrogenic tolerance was accompanied with decaying of the second peak of fever visible as early as the second dose of LPS.

Słowa kluczowe

EN

rectal temperature; pyrogenic tolerance; febrile response; cycloheximide; rabbit; endotoxin

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 1992
• Tom: 43
• Numer: 2
• Opis fizyczny: p.165-171,fig.

Twórcy

autor

Kozak W

• University Medical School, 85-092 Bydgoszcz, Karlowicza 24, Poland

autor

Soszynski D.

autor

Wachulec M.

autor

Szewczenko M.

autor

Bodurka M.

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