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2005 | 52 | 4 |

Tytuł artykułu

Time-dependent effect of leptin on renal Naplus, Kplus-ATPase activity

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Leptin, secreted by adipose tissue, is involved in the pathogenesis of arterial hypertension, however, the mechanisms through which leptin increases blood pressure are incompletely elucidated. We investigated the effect of leptin, administered for different time periods, on renal Na+,K+-ATPase activity in the rat. Leptin was infused under anesthesia into the abdominal aorta proximally to the renal arteries for 0.5-3 h. Leptin administered at doses of 1 and 10 μg/min per kg for 30 min decreased the Na+,K+-ATPase activity in the renal medulla. This effect disappeared when the hormone was infused for ≥1 h. Leptin infused for 3 h increased the Na+,K+-ATPase activity in the renal cortex and medulla. The stimulatory effect was abolished by a specific inhibitor of Janus kinases (JAKs), tyrphostin AG490, as well as by an NAD(P)H oxidase inhibitor, apocynin. Leptin increased urinary excretion of hydrogen peroxide (H2O2) between 2 and 3 h of infusion. The effect of leptin on renal Na+,K+-ATPase and urinary H2O2 was augmented by a superoxide dismutase mimetic, tempol, and was abolished by catalase. In addition, infusion of H2O2 for 30 min increased the Na+,K+-ATPase activity. Inhibitors of extracellular signal regulated kinases (ERKs), PD98059 or U0126, prevented Na+,K+-ATPase stimulation by leptin and H2O2. These data indicate that leptin, by acting directly within the kidney, has a delayed stimulatory effect on Na+,K+-ATPase, mediated by JAKs, H2O2 and ERKs. This mechanism may contribute to the abnormal renal Na+ handling in diseases associated with chronic hyperleptinemia such as diabetes and obesity.

Wydawca

-

Rocznik

Tom

52

Numer

4

Opis fizyczny

p.803-809,fig.,ref.

Twórcy

autor
  • Medical University, Lublin, Poland
autor
autor

Bibliografia

  • Al-Khalili L, Kotova O, Tsuchida H, Ehren I, Feraille E, Krook A, Chibalin AV (2004) ERK1/2 mediates insulin stimulation of Na+,K+-ATPase by phosphorylation of the alpha-subunit in human skeletal muscle cells. J Biol Chem 279: 25211–25218.
  • Beltowski J, Jamroz-Wisniewska A, Nazar J, Wojcicka G (2004a) Spectrophotometric assay of renal ouabain-resistant Na+-ATPase and its regulation by leptin and dietary-induced obesity. Acta Biochim Polon 51: 1003–1014.
  • Beltowski J, Marciniak A, Wojcicka G (2004b) Leptin decreases renal medullary Na+,K+-ATPase activity through phosphatidylinositol 3-kinase dependent mechanism. J Physiol Pharmacol 55: 391–407.
  • Beltowski J, Marciniak A, Jamroz-Wisniewska A, Borkowska E (2004c) Nitric oxide–superoxide cooperation in the regulationof renal Na+,K+-ATPase. Acta Biochim Polon 51: 933–942.
  • Bełtowski J, Jamroz-Wiśniewska A, Borkowska E, Nazar J, Marciniak A (2005) Antioxidant treatment normalizes renal Na+,K+-ATPase activity in hyperleptinemic rats. Pharmacol Rep 57: 219–228.
  • Bouloumie A, Marumo T, Lafontan M, Busse R (1999) Leptin induces oxidative stress in human endothelial cells. FASEB J 13: 1231–1238.
  • Cao Q, Mak KM, Ren C, Lieber CS (2004) Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: respective roles of the JAK/STAT
  • and JAK-mediated H2O2-dependent MAPK pathways. J Biol Chem 279: 4292–4304.
  • Chabrashvili T, Kitiyakara C, Blau J, Karber A, Aslam S, Welch WJ, Wilcox CS (2003) Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression. Am J Physiol 285: R117– R124.
  • Chen YF, Cowley AW Jr, Zou AP (2003) Increased H2O2 counteracts the vasodilator and natriuretic effects of superoxide dismutation by tempol in renal medulla. Am J Physiol 285: R827–R833.
  • Correia ML, Haynes WG (2004) Leptin, obesity and cardiovascular disease. Curr Opin Nephrol Hypertens 13: 215–223.
  • Féraille E, Doucet A (2001) Sodium-potassium-adenosinetriphosphatase- dependent sodium transport in the kidney: hormonal control. Physiol Rev 81: 345–418.
  • Fruhbeck G (2004) The adipose tissue as a source of vasoactive factors. Curr Med Chem Cardiovasc Hematol Agents 2: 197–208.
  • Hegyi K, Fulop K, Kovacs K, Toth S, Falus A (2004) Leptininduced signal transduction pathways. Cell Biol Int 28: 159–169.
  • Hurst RO (1964) The determination of nucleotide phosphorus with a stannous chloride-hydrazine sulphate reagent. Can J Biochem 42: 287–292.
  • Hussain T, Beheray SA, Lokhandwala MF (1999) Defective dopamine receptor function in proximal tubules of obese Zucker rats. Hypertension 34: 1091–1096.
  • Illiano G, Naviglio S, Pagano M, Spina A, Chiosi E, Barbieri M, Paolisso G (2002) Leptin affects adenylate cyclase activity in H9c2 cardiac cell line: effects of shortand long-term exposure. Am J Hypertens 15: 638–643.
  • Isenovic ER, Jacobs DB, Kedees MH, Sha Q, Milivojevic N, Kawakami K, Gick G, Sowers JR (2004) Angiotensin II regulation of the Na+ pump involves the phosphatidylinositol-3 kinase and p42/44 mitogen-activated protein kinase signaling pathways in vascular smooth muscle cells. Endocrinology 145: 1151–1160.
  • Jackson EK, Li P (1997) Human leptin has natriuretic activity in the rat. Am J Physiol 272: F333–F338.
  • Kalinowski L, Maliński T (2004) Endothelial NADH/ NADPH-dependent enzymatic sources of superoxide production: relationship to endothelial dysfunction. Acta Biochim Polon 51: 459–469.
  • Kitiyakara C, Chabrashvili T, Chen Y, Blau J, Karber A, Aslam S, Welch WJ, Wilcox CS (2003) Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase. J Am Soc Nephrol 14: 2775–2782.
  • Lacy F, Kailasam MT, O’Connor DT, Schmid-Schonbein GW, Parmer RJ (2000) Plasma hydrogen peroxide production in human essential hypertension: role of heredity, gender, and ethnicity. Hypertension 36: 878–884.
  • Laroche-Joubert N, Marsy S, Michelet S, Imbert-Teboul M, Doucet A (2002) Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I. J Biol Chem 277: 18598–18604.
  • Laroche-Joubert N, Marsy S, Luriau S, Imbert-Teboul M, Doucet A (2003) Mechanism of activation of ERK and H-K-ATPase by isoproterenol in rat cortical collecting duct. Am J Physiol 284: F948–F954.
  • Lee K, Esselman WJ (2002) Inhibition of PTPs by H2O2 regulates the activation of distinct MAPK pathways. Free Radic Biol Med 33: 1121–1132.
  • Lowry OH, Rosebrough NI, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275.
  • Makino A, Skelton MM, Zou AP, Cowley AW (2003) Increased renal medullary H2O2 leads to hypertension. Hypertension 42: 25–30.
  • Michlig S, Mercier A, Doucet A, Schild L, Horisberger JD, Rossier BC, Firsov D (2004) ERK1/2 controls Na,KATPase activity and transepithelial sodium transport in the principal cell of the cortical collecting duct of the mouse kidney. J Biol Chem 279: 51002–51012.
  • Narkar V, Hussain T, Lokhandwala M (2002) Role of tyrosine kinase and p44/42 MAPK in D2-like receptor-mediated stimulation of Na+,K+-ATPase in kidney. Am J Physiol 282: F697–F702.
  • Shimokawa H, Matoba T (2004) Hydrogen peroxide as an endothelium-derived hyperpolarizing factor. Pharmacol Res 49: 543–549.
  • Sweeney G, Niu W, Kanani R, Klip A (2000) Regulation of the Na,K-pump by leptin in 3T3-L1 fibroblasts. Endocrinology 141: 1277–1280.
  • Swei A, Lacy F, DeLano FA, Schmid-Schonbein GW (1997) Oxidative stress in the Dahl hypertensive rat. Hypertension 30: 1628–1633.
  • Vaziri ND, Dicus M, Ho ND, Boroujerdi-Rad L, Sindhu RK (2003) Oxidative stress and dysregulation of superoxide dismutase and NADPH oxidase in renal insufficiency. Kidney Int 63: 179–185.
  • Yamagishi SI, Edelstein D, Du XL, Kaneda Y, Guzman M, Brownlee M (2001) Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 276: 25096–25100.
  • Yang H, Shi M, VanRemmen H, Chen X, Vijg J, Richardson A, Guo Z (2003) Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice. Am J Hypertens 16: 1–5.
  • Yuen JW, Benzie IF (2003) Hydrogen peroxide in urine as a potential biomarker of whole body oxidative stress. Free Radic Res 37: 1209–1213.
  • Zhan CD, Sindhu RK, Pang J, Ehdaie A, Vaziri ND (2004) Superoxide dismutase, catalase and glutathione peroxidase in the spontaneously hypertensive rat kidney: effect of antioxidant-rich diet. J Hypertens 22: 2025–2033.
  • Zhong Z, Kotova O, Davidescu A, Ehren I, Ekberg K, Jornvall H, Wahren J, Chibalin AV (2004) C-peptide stimulates Na+,K+-ATPase via activation of ERK1/2 MAP kinases in human renal tubular cells. Cell Mol Life Sci 61: 2782–2790.

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Bibliografia

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