Directionality of kinesin motors

• Autorzy: Kasprzak A. A. , Hajdo L.
• Języki publikacji: EN

Abstrakty

EN

Kinesins are molecular motors that transport various cargoes along microtubule tracks using energy derived from ATP hydrolysis. Although the motor domains of kinesins are structurally similar, the family contains members that move on microtubules in opposite directions. Recent biochemical and biophysical studies of several kinesins make it possible to identify structural elements responsible for the different directionality, suggesting that reversal of the motor movement can be achieved through small, local changes in the protein structure.

Słowa kluczowe

EN

movement; X-ray crystallography; microtubule; kinesin; protein structure; mutation; molecular motor; microtubule track

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 4
• Opis fizyczny: p.813-821,fig.

Twórcy

autor

Kasprzak A. A.

• Nencki Institute of Experimental Biology, L.Pasteura 3, 02-093 Warsaw, Poland

autor

Hajdo L.

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