Effect of Ivermectin on the course of Nippostrongylus brasiliensis infection in rats

• Autorzy: Doligalska M , Bezubik B.
• Języki publikacji: EN

Abstrakty

EN

The effect of Ivermectin on the number of cells and the percentage of IgA⁺ cells in bronchial (BLN) and mesenteric (MLN) lymph nodes of rats infected with 3000 L3 of Nippostrongylus brasiliensis was examined. Rats were treated subcutaneously with a dose of 100 pg/kg, 24 h after infection. After treatment, the worm burden was reduced by 90.7% in the parenteral phase and by 98.4% in the enteral phase of the infection. The respiratory tract was still occupied by the fourth stage larvae on day 6 after infection (AI). Adult worms were present in the intestine on day 18 AI while in untreated rats the infection was over already on day 13. No susceptibility to Ivermectin was found in some L4 stage of N. brasiliensis. Larvae trapped in the lungs stimulated very high level of cellular infiltration and IgA⁺ cell proliferation in the BLN. A weak enteral phase, which occurred after treatment with Ivermectin, induced a weak IgA response in the MLN. A temporary effect of Ivermectin which reduced the number of cells in MLN and no effect on the percentage of IgA⁺ cells in the BLN and MLN, were observed.

Słowa kluczowe

EN

infection; Ivermectin; bronchial lymph node; Nippostrongylus brasiliensis; mesenteric lymph node; rat

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 1995
• Tom: 40
• Numer: 3
• Opis fizyczny: p.156-160,fig.

Twórcy

autor

Doligalska M

• University of Warsaw, 00-927 Warsaw, Poland

autor

Bezubik B.

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