Angiotensin-[1-9], the product of angiotensin I conversion in platelets, enhances arterial thrombosis in rats

• Autorzy: Kramkowski K. , Mogielnicki A. , Leszczynska A. , Buczko W.
• Języki publikacji: EN

Abstrakty

EN

Angiotensin (Ang) (1-9) is the renin-angiotensin-system peptide found in the plasma of healthy volunteers and after angiotensin-converting-enzyme inhibitors therapy. In vitro experiments proved that Ang-(1-9) may be produced from Ang I. In our study, we tried to expand the poor data about the in vivo properties of Ang-(1-9). We revealed that Ang-(1-9) enhanced electrically stimulated arterial thrombosis in the carotid artery of Wistar rats. Losartan, a selective blocker of AT1 receptor for Ang II, abolished the prothrombotic activity of Ang-(1-9). This peptide increased plasma level of fibrinogen, augments fibrin generation, and similarly to Ang II, potentiated collagen induced platelet aggregation. Using HPLC, we found that after incubation of Ang-(1-9) with platelet homogenates or after intravenous administration this peptide is converted to Ang II. We concluded that Ang-(1-9) exerts an Ang II-like prothrombotic effect due to the conversion to Ang II in the circulatory system of rats and that platelets are involved in this process.

Słowa kluczowe

EN

angiotensin [1-9]; angiotensin I; conversion; platelet; arterial thrombosis; renin-angiotensin system; fibrin; fibrinogen; angiotensin-converting enzyme inhibitor; rat

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2010
• Tom: 61
• Numer: 3
• Opis fizyczny: p.317-324,fig.,ref.

Twórcy

autor

Kramkowski K.

• Medical University of Bialystok, Mickiewicza Str. 2C, 15-089 Bialystok, Poland

autor

Mogielnicki A.

autor

Leszczynska A.

autor

Buczko W.

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