EN
The aim of the study was to investigate the effects of sodium fluoride (NaF) and nitrate (NO₃⁻) either administered orally alone or in a combination, on the biochemical parameters of rats. Tests on general toxicity were conducted on the basis of methodical recommendations 408 of the Organisation for Economic Co-operation and Development Guideline for Testing of Chemicals: "Subchronic Oral Toxicity - Rodent: 90-d Study".The following combined effects of the tested chemicals were predominantly observed: additive, synergistic, and antagonistic. Methaemoglobinaemia was noted in groups given NO₃⁻ or NaF + NO₃⁻ complex.