Selectivity of oxidative stress targeting in estrogen-induced experimental nephrocarcinogenesis

• Autorzy: Kobiela J. , Krajewski J. , Kalinska-Blach B. , Stefaniak T.
• Języki publikacji: EN

Abstrakty

EN

Specificity of targeting of the oxidative stress towards lipid and protein fractions in a model of estrogen-induced Syrian hamster nephrocarcinogenesis was evaluated. The amount of proteins modified by oxidative stress was significantly elevated as early as one month after the initial implantation of estradiol to the experimental ver­sus the control group, while the stress did not affect lipids. Subcellular localization of the oxidative stress target was determined by the analysis of protein oxidation in subcellular fractions of kidney cells. The endoplasmic reticulum membranes were the fraction most affected by the oxidative stress.

Słowa kluczowe

EN

Syrian hamster; nephrocarcinogenesis; male; oxidative stress; kidney; protein carbonyl group; estrogen-induced carcinogenesis; hamster; renal carcinogenesis; cancer

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 1
• Opis fizyczny: p.51-58,fig.

Twórcy

autor

Kobiela J.

• Medical University of Gdansk, Prof.Kieturakis 1, 80-742 Gdansk, Poland

autor

Krajewski J.

autor

Kalinska-Blach B.

autor

Stefaniak T.

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