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2007 | 14 | 6 |

Tytuł artykułu

Antyoksydanty w profilaktyce i terapii cukrzycy typu II

Treść / Zawartość

Warianty tytułu

EN
Antioxidants for the prevention and therapy of type 2 diabetes

Języki publikacji

PL

Abstrakty

PL
Stres oksydacyjny w cukrzycy jest skutkiem wysokich stężeń glukozy i kwasów tłuszczowych. Odgrywa istotną rolę w patogenezie cukrzycy i jej powikłań. Jego patogenne działanie polega między innymi na hamowaniu syntezy insuliny w trzustkowych komórkach beta i hamowaniu przeniesienia sygnału insulinowego w komórkach docelowych. Działanie to przyczynia się do rozwoju insulinooporności oraz indukowania zmian w ścianach naczyń krwionośnych prowadzących do powikłań cukrzycy. Stwierdzono działanie antydiabetyczne takich przeciwutleniaczy, jak: witamina E, karotenoidy, różne polifenole. Właściwości przeciwutleniające wykazują rośliny lecznicze stosowane w medycynie ludowej różnych stron świata, dzięki czemu wiele z nich wykazuje działanie antydiabetyczne.
EN
Oxidative stress in diabetes is a result of high concentration levels of glucose and fatty acids. It plays a key role in the pathogenesis of diabetes and its complications. Its pathogenic action consists, among other things, in suppressing the synthesis of insulin in pancreatic β-cells, as well as in hampering the insulin signal transmission in target cells. This action contributes to the development of insulin resistance and induces changes in vascular walls, thus, causing diabetic complications. It was found that some antioxidants had anti-diabetic activity, for example: vitamin E, carotenoids, and various polyphenols. Medical plants used by folk medicine in different world regions have antioxidative features, and, therefore, many of those plants show anti-diabetic activity.

Wydawca

-

Rocznik

Tom

14

Numer

6

Opis fizyczny

s.62-70,bibliogr.

Twórcy

  • Szkola Glowna Gospodarstwa Wiejskiego, ul.Nowoursynowska 159C, 02-776 Warszawa

Bibliografia

  • [1] Babu P.V., Sabitha K.E., Shyamaladevi C.S.: Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. Chem. Biol. Interact., 2006, 162, 114 – 120.
  • [2] Brownlee M.: Biochemistry and molecular cell biology of diabetic complications. Nature, 2001, 414, 813-820.
  • [3] Bursell S.E., Clermont A.C., Aiello L.P., Aiello L.M., Schlossman D.K., Feener E.P., Laffel I., King G.I.: High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type I diabetes. Diabetes Care, 1999, 22, 1245-1251.
  • [4] Ceriello A., Bortolotti N., Motz E., Lizzio S., Catone B., Assaloni R., Tonutti L., Taboga C.: Red wine protects diabetic patients from meal-induced oxidative stress and thrombosis activation: a pleasant approach to the prevention of cardiovascular disease in diabetes. Eur. J. Clin. Invest., 2001, 31, 322-328.
  • [5] Can A., Akev N., Ozsov N., Bolken S., Arda B.P., Yanardag R., Okyar A.: Effect of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models. Biol. Pharm. Bull, 2004, 27, 694-698.
  • [6] Cho E.J., Lee Y.A., Yoo H.H., Yokozawa T.: Protective effects of broccoli (Brassica oleracea) against oxidative damage in vitro and in vivo. J. Nutr. Sci.Vitaminol., 2006, 52, 437- 444.
  • [7] DECODE Study Group: Age- and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European Cohorts. Diabetes Care, 2003, 26, 61-69.
  • [8] Evans J.L., Goldfine I.D., Maddux B.A., Grodsky G.M.: Oxidative stress and stress-activated signalling pathways: a unifying hypothesis of type II diabetes. Endocrine Rev., 2002, 23, 599-622.
  • [9] Feskens E.J.M., Virtanen S.M., Rasanen L., Tuomilehto J., Stengard J., Pekkanen J., Nissinen J., Kromhaut D.: Dietary factors determining diabetes and impaired glucose tolerance: a 20-year follow up of the Finnish and Dutch cohorts of the Seven Countries Study. Diabetes Care, 1995, 18, 1104-1112.
  • [10] Harmon A., Patel Y.M.: Naringerin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun., 2003, 305, 229-234.
  • [11] Jarvill-Taylor J.K., Anderson R.A., Graves D.J.: A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. Am. Coll. Nutr., 2001, 4, 327-336.
  • [12] Jenkins D.J., Kendall C.W., Josse A.R., Salvatore S., Brighenti F., Augustin L.S., Ellis P.R., Vidgen E., Rao A.V.: Almonds decrease postprandial glycemia, insulinemia, and oxidative damage in healthy individuals. J. Nutr., 2006, 136, 2987-2992.
  • [13] Kamei R.K.M., Kitagawa Y., Hazeki O., Oikawa S.: 2’-Benzyloxychalcone derivatives stimulate glucose uptake in 3T3-L1 adipocytes. Life Sci., 2003, 73, 2091-2099.
  • [14] Kaneto H., Xu G., Song K.-H., Suzuma K., Bonner-Weir S., Sharma A., Weir G.C.: Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function by provoking oxidative stress, J. Biol. Chem., 2001, 276, 31099-31104.
  • [15] Kaneto H., Matsuoka T., Nakatani Y., Kawamori D., Miyatsuka T., Matsuhisa M., Yamasaki Y.: Oxidative stress, ER stress, and the JNK pathway in type II diabetes. J. Mol. Med., 2005, 83, 429-439.
  • [16] Kesavulu M.M., Giri R., Rao B.K., Apparao Ch.: Lipid peroxidation and antioxidant enzyme levels in type 2 diabetics with microvascular complications. Diabetes and Metabolism (Paris), 2000, 26, 387-392.
  • [17] Kędziora-Kornatowska K.Z., Luciak M., Błaszczyk J., Pawlak W.: Lipid peroxidation and activities of antioxidant enzymes in erythrocytes of patients with non-insulin dependent diabetes with or without diabetic nephropathy. Nephrol. Dial. Transplant., 1998, 13, 2829-2832.
  • [18] Kim H.Y., Yokozawa T., Cho E.J., Cheigh H.S., Choi J.S., Hung H.Y.: In vitro and in vivo antioxidant effects of mustard leaf (Brassica Juncea). Phytother. Res., 2003, 17, 465-471.
  • [19] Kowluru R.A., Kanwar M.: Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr. Metab., 2007, www.nutrionandmetabolism.com/content/4/1/8
  • [20] Landrault N., Poucheret P., Azay J., Krosniak M., Gasc F., Jenin C., Cros G., Teissedre P.L.: Effect of polyphenols-enriched chardonnay white wine in diabetic rat. J. Agric. Food Chem., 2003, 51, 311-318.
  • [21] Mayer-Davis E.J., Costacou T., King I., Zaccaro D.J., Bell R.A.: Plasma and dietary vitamin E in relation to incidence of type II diabetes: the Insulin Resistance and Atherosclerosis Study (IRAS). Diabetes Care, 2002, 25, 2172-2177.
  • [22] Montonen J., Jarvinen R., Knekt P., Reunanen A.: Dietary antioxidant intake and risk of type II diabetes. Diabetes Care, 2004, 27, 362-366.
  • [23] Murugesh K., Yeligar V., Dash D.K., Sengupta P., Maiti B.Ch., Maiti T.K.: Antidiabetic, antioxidant and antihyperlipidemic status of Heliotropium zeylanicum extract on streptozotocin-induced diabetes in rats. Biol. Pharm. Bull., 2006, 29, 2202-2205.
  • [24] Neri S., Signorelli S.S., Torrisi B., Pulvirenti D., Mauceri B., Abate G., Ignaccolo L., Bordonaro F., Cilio D., Calvagno S., Leotta C.: Effects of antioxidant supplementation on postprandial oxidativestress and endothelial dysfunction: a single blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls. Clin. Ther., 2005, 27, 1764-1773.
  • [25] Pari L., Latha M.: Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipid peroxidation in STZ diabetic male Wistar rats. BMC Complement. Altern. Med., 2004, www.biomedcentral.com/1472-6882/4/16.
  • [26] Pinent M., Blay M., Blade M.C., Salvado M.J., Arola L., Ardevol A.: Grape seed-derived procyanidin have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology, 2004, 145, 4985-4990.
  • [27] Salonen J.T., Nyssonen K., Tuomainen T.-P., Maenpaa P.H., Korpela H., Kaplan G.A., Lynch J., Helmrich S.P., Salonen R.: Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men. BMJ, 1995, 311, 1124-1127.
  • [28] Suzuki Y.A., Tomoda M., Murata Y., Inui H., Sugiera M., Nakano Y.: Antidiabetic effesct of longterm supplementation with Siraitia grosvenori on the spontaneously diabetic Goto-Kakizaki rat. Br. J. Nutr., 2007, 97, 770-775.
  • [29] Tuncay E., Seymen A.A., Tanriverdi E., Yaras N., Tandogan B., Ulusu N.N., Turan B.: Gender related differential effects of omega-3E treatment on diabetes-induced left ventricular dysfunction. Moll. Cell. Biochem., DOI 10.1007/s11010-007-9508-4.
  • [30] Ugochukwu N.H., Babady N.N.: Antihyperglycemic effect of aqueous and ethanolic extracts of Gongronema latifolium leaves on glucose and glycogen metabolism in livers of normal and streptozotocin-induced diabetic rats. Life Sci, 2003, 73, 1925-1938.
  • [31] Ugochukwu N.H., Cobourne M.K.: Modification of renal oxidative stress and lipid peroxidation in streptozotocin-induced diabetic rats treated with extracts from Gongronema latifolium leaves. Clin. Chim. Acta, 2003, 336, 73-81.
  • [32] Vessal M., Hemmati M., Vasei M.: Antidiabetic effects of quercetin in streptozotocin-induced diabetic rats. Comp. Biochem. Physiol. C., 2003, 135, 357-364.
  • [33] Waltner-Law M., Wang X.L., Law B.K., Hall R.K., Nawano M., Granner D.K.: Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J. Biol. Chem., 2002, 277, 34933-34940.
  • [34] Winterbone M.S., Sampson M.J., Saha S., Hughes J.C., Hughes D.A.: Pro-oxidant effect of α-tocopherolin patients with type 2 diabetes after an oral glucose tolerance test – a randomized controlled trial. Cardiovasc. Diabetol., 2007, 22, 6:8.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-5f775cfa-aade-42ee-a1ee-8e8d531abd9b
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