Embryotoxic and teratogenic action of trypsin inhibitor of Ascaris lumbricoides in mice

• Autorzy: Blaszkowska J
• Języki publikacji: EN

Abstrakty

EN

Trypsin inhibitor isolated from Ascaris lumbricoides suis and injected into pregnant BALB/c mice disturbed prenatal development of mice fetuses. The nature and intensity of prenatal disturbances in development are determined by the trypsin inhibitor dose. The symptoms that occurred after administration of the highest doses of Ascaris trypsin inhibitor to pregnant mice included: decreased body weight gain (p<0.05) as compared to controls, bleeding from the uterus, abortions and mortality. All doses of trypsin inhibitor exhibited an embryotoxic effect. Trypsin inhibitor significantly decreased the number of fetuses per litter, increased the frequency of litter resorption, produced a delay in bone formation and included pathological changes. Teratogenic effects of trypsin inhibitor were apparent in fetuses after doses of 200-400 mg per kg. The most frequent developmental defects were: cleft palate, fusion of ribs and micrognathia. No defects were noted in control groups. The trypsin inhibitor from Ascaris is a substance of considerable biological activity, which may be important in the outcome of the host-parasite relationship. It may be also a parasite pathogenic factor.

Słowa kluczowe

EN

uterus; pregnant mice; embryotoxic action; mammal; mortality; trypsin inhibitor; embryotoxic effect; host; toxic influence; body weight; fetus; stress; Ascaris lumbricoides suis; rib fusion; vital nutrient; mice; endocrinal gland; teratogenic action; pathological change; mouse; cleft palate; sexual organ; abortion; parasitic infection; micrognathia

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 1998
• Tom: 43
• Numer: 2
• Opis fizyczny: p.103-108

Twórcy

autor

Blaszkowska J

• Department of Biology and Medical Parasitology, Medical University of Lodz, Kosciuszki 85, 90-436 Lodz, Poland

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