Vascular function and nitric oxide production in chronic social-stress-exposed rats with various family history of hypertension

• Autorzy: Bernatova I. , Csizmadiova Z. , Kopincova J. , Puzserova Z.
• Języki publikacji: EN

Abstrakty

EN

The study investigated the effect of chronic crowding stress on vascular function and nitric oxide (NO) production in rats with various family history of hypertension. Wistar (W), wBHR (offspring of W dams and spontaneously hypertensive sires), sBHR (offspring of spontaneously hypertensive dams and W sires) and spontaneously hypertensive rats (SHR) were used. Twelve-week-old males were divided into the control or crowded group for eight weeks. Basal blood pressure (BP, determined by tail-cuff plethysmography) of W, wBHR, sBHR and SHR rats was 112 ± 3, 129 ± 2, 135 ± 2 and 187 ± 3 mmHg, respectively. Crowding increased BP and reduced aortic NO synthase activity only in sBHR and SHR rats, without alterations in hypothalamic NO production. Acetylcholine-induced vasorelaxation of the femoral artery of stress-exposed rats was improved in W, unaltered in wBHR and sBHR and reduced in SHR. Crowding reduced serotonin-induced vasoconstriction in W and wBHR rats but had no effect in sBHR and SHR rats. In conclusion, the results suggest that crowded offspring of normotensive mothers were able to modify their vascular function in order to maintain BP at normal levels. On the other hand, offspring of hypertensive mothers were unable of effective adaptation of vascular function in stressful conditions resulting in gradual development of hypertension.

Słowa kluczowe

EN

vascular function; production; genetic predisposition; nitric oxide; hypertension; social stress; rat; crowding; stress-induced hypertension

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2007
• Tom: 58
• Numer: 3
• Opis fizyczny: p.487-501,fig.,ref.

Twórcy

autor

Bernatova I.

• Slovac Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovak Republic

autor

Csizmadiova Z.

autor

Kopincova J.

autor

Puzserova Z.