Increased expression of ribosomal protein S2 in liver tumors, posthepactomized livers, and proliferating hepatocytes in vitro

• Autorzy: Kowalczyk P. , Woszczynski M. , Ostrowski J.
• Języki publikacji: EN

Abstrakty

EN

The ribosomal protein S2 (RPS2) is encoded by a gene from the highly conserved mammalian repetitive gene family LLRep3. It participates in aminoacyl-transfer RNA binding to ribosome, potentially affecting the fidelity of mRNA translation. These studies were designed to measure the expression of RPS2 during increased cell prolif­eration. Using Western and Northern blot analyses, we found that the levels of RPS2 protein and its corresponding mRNA were higher in mouse hepatocellular carcinoma, in mouse livers after one-third partial hepatectomy, and in serum-starved cultured hepatocytes following serum treatment. Our study shows that the increased expres­sion of RPS2 correlates with increased cell proliferation. However, whether the al­tered expression of this protein reflects its involvement in cellular proliferation or represents an associated phenomena is still a key question that needs to be explored.

Słowa kluczowe

EN

cell proliferation; carcinoma; hepatocellular carcinoma; hepatocyte; proliferating hepatocyte; liver; ribosomal protein; in vitro; tumour; expression; malignancy

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 3
• Opis fizyczny: p.615-624,fig.

Twórcy

autor

Kowalczyk P.

• Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, W.C.Roentgena 5, 02-781 Warsaw, Poland

autor

Woszczynski M.

autor

Ostrowski J.

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