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2006 | 62 | 12 |

Tytuł artykułu

Wplyw meloksykamu na nieswoiste komorkowe i humoralne mechanizmy obronne u bydla

Warianty tytułu

EN
Influence of meloxicam on cellular and humoral defense mechanisms

Języki publikacji

PL

Abstrakty

EN
The aim of the study was to determine the influence of meloxicam a nonsteroid anti-inflammatory drug, on nonspecific cellular and humoral defense mechanisms in cows. Ten heifers in two groups (experimental and control) were examined. Meloxicam was given once only to the experimental group during the course of the study. The levels of lysozyme activity and total protein as well as ceruloplasmine, gamma globulin and metabolic activity (RB A), the killing activity of macrophages (PKA) and proliferate response of lymphocyte were measured in the blood. The results indicate the immunosuppressive effect of Meloxicam on nonspecific cellular and humoral responses which, in practice, could appear as an increased sensitivity to infection, a decrease in post-vaccine immunity as well as the occurrence of various asymptomatic infections.

Wydawca

-

Rocznik

Tom

62

Numer

12

Opis fizyczny

s.1400-1402,tab.,bibliogr.

Twórcy

autor
  • Uniwersytet Warminsko-Mazurski, ul.Oczapowskiego 13, 10-957 Olsztyn
autor
autor

Bibliografia

  • 1.Amberger A., Hala M., Saurwein-Teissl M., Metzler B., Grubeck-Loebenstein B., Xu Q., Wick G.: Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction ofheat Srock proteins. Mol. Med. 1999, 5, 117-128.
  • 2.Bednarek D., Zdzisiñska B., Kondracki M., Kandefer-Szerszeñ M.: Effect of steroidal and non-steroidal anti-inflammatory drugs in combination with longacting oxytetracycline on non-specific immunity of calves suffering from enzootic bronchopneumonia. Vet. Microbiol. 2003, 96, 53-67.
  • 3.Berg J., Fellier H., Chritoph T., Grarup J., Stimmender D.: The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX) -1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL) -6 in vitro. Inflamm. Res. 1999, 48, 369-379.
  • 4.Bevilacqua M., Magni E.: Recent contributions to knowledge of the mechanism of action of nimesulide. Drugs. 1993, 46, 40-47.
  • 5.Chung S., Secombes S. J.: Analysis of events occurring within teleost macrophages during the respiratory burst. Comp. Biochem. Physiol. 1988, 89B, 539-544.
  • 6.Emery P.: Clinical aspects of COX-2 inhibitors. Drugs Today (Barc.) 1999, 35, 267-274.
  • 7.Hayes E. C, Rock J. A.: COX-2 inhibitors and their role in gynecology. Obstet. Gynecol. Surv. 2002, 57, 768-780.
  • 8.Kurumbail R. G., Stevens A. M., Gierse J. K., McDonald J. J., Stegeman R. A., Park J. Y., Gildehaus D., Miyashiro J. M., Penning T. D., Seibert K., Isakson P. C., Stallings W. C.: Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature 1996, 384, 644-648.
  • 9.Lowry O. H., Rosebrough N. J., Farr A. L., Randall R.: Protein measurements with the folin phenol reagent. J. Biol. Chem. 1951, 193, 265-275.
  • 10.Międzybrodzki R.: Kierunki poszukiwañ i zastosowanie niesteroidowych leków przeciwzapalnych. Postępy Hig. Med. Dosw. 2004, 58, 438-448.
  • 11.Mosmann T.: Rapidcolorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 1983, 65, 55-63.
  • 12.Parry R. M., Chandau R. C., Shahani R. M.: A rapid and sensitive assay of muramidase. Proc. Soc. Exp. Biol. Med. 1965, 119, 384-386.
  • 13.Rice E. W., Wagman E., Takenaka Y.: Ceruloplazmin assay in serum: standardization of ceruloplazmin activity in terms of international enzyme units. Diag. Lab. 1986, 12, 39-53.
  • 14.Rook G. A., Steele W., Umar J., Dockrell H. M.: A simple method for the solubilization of reduced NBT and its use as a colorimetricassay for activation of human macrophages by gamma interferon. J. Immunol. Meth. 1995, 82, 161-167.
  • 15.Sano H., Kawahito Y., Wilder R. L., Hashiramoto A., Mukai S., Asai K., Kimura S., Kato H., Kondo M., Hla T.: Expression of cyclooxygenase-1 and -2 in human colorectal cancer. 1995, 17, 3785-3789.
  • 16.Siwicki A. K., Anderson D. P.: Immunostimulation in fish: Measuring the effects of stimulants by serological and immunological methods. U.S. Fish Wildl. Service-IFI, Olsztyn 1993, 1, 17.
  • 17.Wu K. K., Sanduja R., Tsai A. L., Ferhanoglu B., Loose-Mitchell D. S.: Aspiryn inhibits interleukiny 1 induced prostaglandyn H sythase expression in cultured endothelial cells. Proc. Natl. Acad. Sci. 1991, 88, 2384-2387.
  • 18.Vane J. R.: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature 1971, 231, 232-235.
  • 19.Verhoeven A. J., Tool A. T. J., Kuijpers T. W., Roos D.: Nimesulide inhibits platelet-activating factor synthesis in activated human neutrofils. Drugs. 1993, 46, 52-58.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-5ccef358-076d-4035-b0e8-496b0073c357
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