EN
The aim of the study was to determine the influence of meloxicam a nonsteroid anti-inflammatory drug, on nonspecific cellular and humoral defense mechanisms in cows. Ten heifers in two groups (experimental and control) were examined. Meloxicam was given once only to the experimental group during the course of the study. The levels of lysozyme activity and total protein as well as ceruloplasmine, gamma globulin and metabolic activity (RB A), the killing activity of macrophages (PKA) and proliferate response of lymphocyte were measured in the blood. The results indicate the immunosuppressive effect of Meloxicam on nonspecific cellular and humoral responses which, in practice, could appear as an increased sensitivity to infection, a decrease in post-vaccine immunity as well as the occurrence of various asymptomatic infections.