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2006 | 11 | 1 |

Tytuł artykułu

The protective effects of selenoorganic compounds against peroxynitrite-induced changes in plasma proteins and lipids

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Many selenoorganic compounds play an important role in biochemical processes and act as antioxidants, enzyme inhibitors or drugs. The effects of a new selenocompound — bis(2-aminophenyl)-diselenide on oxidative/nitrative changes in human plasma proteins induced by peroxynitrite (ONOO−) were studied in vitro and compared with the those of ebselen, a well-known antioxidant. We also studied the role of the tested selenocompounds in peroxynitrite-induced plasma lipid peroxidation. Exposure of the plasma to peroxynitrite (0.1 mM) resulted in an increase in the level of carbonyl groups and nitrotyrosine residues in plasma proteins (estimated using the ELISA method and Western blot analysis). In the presence of different concentrations (0.025–0.1 mM) of the tested selenocompounds, 0.1 mM peroxynitrite caused a distinct decrease in the level of carbonyl group formation and tyrosine nitration in plasma proteins. Moreover, these selenocompounds also inhibited plasma lipid peroxidation induced by ONOO−1 (0.1 mM). The obtained results indicate that in vitro bis(2-aminophenyl)-diselenide and ebselen have very similar protective effects against peroxynitrite-induced oxidative/nitrative damage to human plasma proteins and lipids.

Wydawca

-

Rocznik

Tom

11

Numer

1

Opis fizyczny

p.1-11,fig.,ref.

Twórcy

autor
  • University of Lodz, Banacha 12/16, 90-237 Lodz, Poland
autor
autor

Bibliografia

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  • 2. Gromer, S., Johansson, L., Bauer, H., Arscott, L.D., Rauch, S., Ballou, D.P., Williams, C.H., Jr., Schirmer, R.H. and Arner, E.S. Active sites of thioredoxin reductases: why selenoproteins? Proc. Natl. Acad. Sci. USA 100 (2003) 12618-12623.
  • 3. Rotruck, J.T., Pope, A.L., Ganther, H.E., Swanson, A.B., Hafeman, D.G. and Hoekstra, W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science 179 (1973) 588-590.
  • 4. Low, S.C. and Berry, M.J. Knowing when not to stop: selenocysteine incorporation in eukaryotes. Trends Biochem. Sci. 21 (1996) 203-208.
  • 5. Schewe, T. Molecular actions of ebselen – an antiinflammatory antioxidant. Gen. Pharmacol. 26 (1995) 1153-1169.
  • 6. Furstenau, C.R., Spier, A.P., Rucker, B., Luisa, B.S., Battastini, A.M. and Sarkis, J.J. The effect of ebselen on adenine nucleotide hydrolysis by platelets from adult rats. Chem. Biol Interact. 148 (2004) 93-99.
  • 7. Lindenblatt, N., Schareck, W., Belusa, L., Nickels, R.M., Menger, M.D. and Vollmar, B. Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression. Thromb. Haemost. 90 (2003) 882-892.
  • 8. Sies, H. Ebselen, a selenoorganic compound as glutathione peroxidase mimic. Free Radic. Biol Med. 14 (1993) 313-323.
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  • 10. Beckman, J.S., Beckman, T.W., Chen, J., Marshall, P.A. and Freeman, B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87 (1990) 1620-1624.
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  • 12. Arteel, G.E., Briviba, K. and Sies, H. Protection against peroxynitrite. FEBS Lett. 445 (1999) 226-230.
  • 13. Groves, J.T. Peroxynitrite: reactive, invasive and enigmatic. Curr. Opin. Chem. Biol. 3 (1999) 226-235.
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  • 15. Olas, B., Nowak, P., Kolodziejczyk, J., Ponczek, M. and Wachowicz, B. Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitrite. J. Nutr. Biochem. 17 (2005) 96-102.
  • 16. Olas, B., Nowak, P., Kolodziejczyk, J. and Wachowicz, B. The effects of antioxidants on peroxynitrite-induced changes in platelet proteins. Thromb. Res. 113 (2004) 399-406.
  • 17. Khan, J., Brennand, D.M., Bradley, N., Gao, B., Bruckdorfer, R. and Jacobs, M. 3-Nitrotyrosine in the proteins of human plasma determined by an ELISA method. Biochem. J. 330 (1998) 795-801.
  • 18. Buss, H., Chan, T.P., Sluis, K.B., Domigan, N.M. and Winterbourn, C.C. Protein carbonyl measurement by a sensitive ELISA method. Free Rad. Biol. Med. 23 (1997) 361-366.
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  • 22. Pignatelli, B., Li, C.Q., Boffetta, P., Chen, Q., Ahrens, W., Nyberg, F., Mukeria, A., Bruske-Hohlfeld, I., Fortes, C., Constantinescu, V., Ischiropoulos, H. and Ohshima, H. Nitrated and oxidized plasma proteins in smokers and lung cancer patients. Cancer Res. 61 (2001) 778-784.
  • 23. Pannala, A.S., Rice-Evans, C.A., Halliwell, B. and Singh, S. Inhibition of peroxynitrite-mediated tyrosine nitration by catechin polyphenols. Biochem. Biophys. Res. Commun. 232 (1997) 164-168.
  • 24. Radi, R., Beckman, J.S., Bush, K.M. and Freeman, B.A. Peroxynitriteinduced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch. Biochem. Biophys. 288 (1991) 481-487.
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-5c87f8c0-0cdb-4e04-b5bd-260b23194b13
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