Effects of acetylsalicylic acid and a new pyrazine derivative PD-101 on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes

• Autorzy: Wozniak A , Limon J. , Petrusewicz J. , Kaliszan R.
• Języki publikacji: EN

Abstrakty

EN

Acetylsalicylic acid (ASA) and α-2-pyrazylidene-α-cyano N-butyl acetamide (PD-101), a new antiaggregatory pyrazine derivative were tested for their genotoxicity in human lymphocytes in vitro using the sister chromatid exchange (SCE) technique. Both compounds were found to be inactive in inducing SCE in concentration from 1 µM up to 1000 µM. The agents displayed inhibitory effect on cell kinetics.

Słowa kluczowe

EN

pyrazine; cell cycle; human lymphocyte; cytogenetic analysis; sister chromatid exchange; kinetics; chromosome aberration; in vitro; acetylsalicylic acid

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 1998
• Tom: 39
• Numer: 3
• Opis fizyczny: p.281-287

Twórcy

autor

Wozniak A

• Medical University, Debinki 1, 80-210 Gdansk, Poland

autor

Limon J.

autor

Petrusewicz J.

autor

Kaliszan R.

Bibliografia

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