Residues of dimethoate in the liver and AChE activity in blood of rats after exposure to dimethoate, and dimethoate and pyrantel embonate

• Autorzy: Barski D. , Zasadowski A.
• Języki publikacji: EN

Abstrakty

EN

The study was aimed at determining the dimethoate residues in the liver and acetylcholinesterase (AChE) activity in blood of rats exposed to dimethoate (individual intoxication), and dimethoate and pyrantel embonate (simultaneous intoxication). The experiment was carried out in two stages where various doses of preparations and exposure manners were used. In the first stage of the experiment, dimethoate (1/25 LD50) was administered to animals per os for 28 days, and pyrantel embonate (1/2 LD50) twice, i.e. on the day 14th and 28lh. In the second stage, dimethoate was administered for 5 days (1/10 LD50), and pyrantel embonate (1/5 LD50) on day 3, 4 and 5 from the beginning of dimethoate intoxication. The short presence of the dimethoate residues in the liver of the animals examined was found until the 2"d day after 28-day intoxication (1/25 LD50) and until 14th day after 5-day intoxication (1/10 LD50), however, a distinct decrease in this insecticide residues in the liver of (analysed groups of) rats occurred between the 3rd hour and the 2nd day after exposure. Dimethoate in both applied doses significantly reduced AChE activity in blood. After application of the higher dose, the inhibition of AChE was more pronounced, and the return of its activity to physiological values lasted considerably longer. Co-administration of pyrantel embonate and dimethoate, slightly influenced changes of the parameters analysed, which have been dependent not only on a dose and manner of pyrantel application but also on time which lapsed from exposure.

Słowa kluczowe

EN

residue; veterinary medicine; acetylcholinesterase; blood; pyrantel embonate; exposure; liver; dimethoate; rat

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2006
• Tom: 09
• Numer: 1
• Opis fizyczny: p.43-49,fig.,ref.

Twórcy

autor

Barski D.

• University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland

autor

Zasadowski A.

Bibliografia

• Abou-Donia MB (2003) Organophosphorus ester-induced chronic neurotoxicity. Arch Environ Health 58: 484-497.
• Abu-Qare AW, Abou-Donia MB (2001) Inhibition and re­covery of maternal and fetal cholinesterase enzyme activ­ity following a single cutaneous dose of methyl parathion and diazinon, alone and in combination, in pregnant rats. J Appl Toxicol 21: 307-316.
• Afifi NA, Ramadan A, el-Aziz MI, Saki EE (1991) Influence of dimethoate on testicular and epididymal organs, tes­tosterone plasma level and their tissue residues in rats. Dtsch Tierarztl Wocheschr 98: 419-423.
• Aprea C, Terenzoni B, Angelis VDe, Sciarra G, Lunghini L, Borzacchi G, Vasconi D, Fani D, Quercia A, Salvan A, Settimi L (2004) Evaluation of Skin and Respiratory Doses and urinary Excretion of Alkylphosphates in Workers Exposed to Dimethoate During Treatment of Olive Trees. Arch Environ Contam Toxicol 48: 127-134.
• Aysal P, Tiryaki O, Tuncbilek AS (2004) 14C-Dimethoate Residues in Tomatoes and Tomato Products. Bull En­viron Contam Toxicol 73: 351-357.
• Bapiro TE, Egnell AC, Hasler JA, Masimirembwa CM (2001) Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos 29: 30-35.
• Baranowa NP, Aleksandrova LG, Kovalenko VF (1986) Tis­sue distribution and biochemical effects of dimethoate entering the body via the skin. Gig Tr Prof Zabol 3: 20-23.
• Barski D, Zasadowski A (1997) The effects of toxic activity of lead and selected phosphoorganic insecticides in rats. II. Acetylcholinesterase activity (AChE) assessment in the blood and brain of rats intoxicated with lead, fenit- rothion and foschlor as well as with combinations of leadwith fenitrothion and foschlor. Acta Acad Agricult Tech Olst Veterinaria 25: 101-111.
• Churchill D, Churchill DJ, Will RG (1999) Organophos- phatc exposure and variant Creutzfeldt-Jakob disease. Lancet 353: 1410,
• Deike S, Wosnitzka H (1989) Behavior of serum cholines­terase and acetylcholinesterase activity in acute dimethoate poisoning. Z Gesamte Inn Med 44: 548-549.
• Dongren Y, Tao L, Fengsheng H (1999) Elec- troneurophysiological studies in rats of acute dimethoate poisoning. Toxicol Lett 107: 249-254.
• Getenga ZM, Jondiko JIO, Wandiga SO, Beck E (2000) Dissipation Behavior of Malathion and Dimethoate Resi­dues from the Soil and Their Uptake by Garden Pea (Pisum sativum). Bull Environ Contam Toxicol 64: 359- -367.
• Gokbulut C, Nolan AM, Mckellar OA (2001) Phar­macokinetic disposition and faecal excretion of pyrantel embonate following oral administration in horses. J Vet Pharmacol Ther 24: 77-79.
• Horton J (2003) Global anthelmintic chemotherapy pro­grams: learning from history. Trends in Pathol 19: 405- -409.
• Karanth S, Olivier K, Liu J, Pope C (2001) In vivo interac­tion between chlorpyrifos and parathion in adult rats: se­quence of administration can markedly influence toxic outcome. Toxicol Appl Pharmacol 177: 247-255.
• Mileson BE, Chambers JE, Chen WL, Dettbarn W (1998) Common mechanism of toxicity: a case study of or- ganophosphorus pesticides. Toxicol Sci 41: 8-20.
• Ruckebusch Y, Ruckebusch M (1961) Sur le système acetyl­cholinesterase et la pharmacologie des insecticides or- ganophosphores. Cah Med Vet 30: 126-151.
• Sharma Y, Bashir S., Irshad M, Gupta SD, Dogra TD (2005) Effects of acute dimethoate administration on anti­oxidant status of liver and brain of experimental rats. Toxicology 206: 49-57.
• Siller FR, Quintanilla-Vega B, Cebrian ME, Albores A (1997) Effects of arsenite pretreatment on the acute toxicity of parathion. Toxicology 116: 59-65.
• Soliman KM (2001) Changes in concentration of pesticide residues in potatoes during washing and home prepara­tion. Food Chem Toxicol 39: 887-891.
• Storm JE, Rozman KK, Doull J (2000) Occupational expo­sure limits for 30 organophosphate pesticides based on inhibition of red blood cell acetylcholinesterase. Toxicol­ogy 150: 1-29.
• Vale JA (1998) Toxicokinetic and toxicodynamic aspects of organophosphorus (OP) insecticide poisoning. Toxicol Lett 102-103: 649-652.
• WHO (1996) Report of the WHO Informal Consultation on hookworm infection and anaemia in girls and women. Division of Control of Tropical Diseases, WHO/CTD/SIP.96.1. Geneva, pp 25-32.
• Zasadowski A, Barski D (1999) The effects of cadmium chloride and fenitrothion administration on the activity of acetylcholine esterase (AChE) and fenitrothion residues in broiler chicken. Bromat Chem Toxicol 32: 143-148.
• Zasadowski A, Barski D, Spodniewska A (1997) The effect of lead and selenium on the residue levels of phos- phoro-organic insecticides in rat tissues. Acta Pol Toxicol 5: 63-71.