The effect of poneratoxin on neuromuscular transmission in the rat diaphragm

• Autorzy: Hendrich A B , Mozrzymas J.W. , Konopinska D. , Scuka M.
• Języki publikacji: EN

Abstrakty

EN

The effect of the ant venom neuropeptide - poneratoxin (PoTX) - on neuromuscular transmission in rat diaphragm tissue was studied by means of intracellular recordings of spontaneous miniature endplate potentials (MEPPs) and of nerve evoked endplate potentials (EPPs). A 2 µM concentration of PoTX caused a pronounced but transient increase in MEPPs frequency. Moreover, within the first few minutes of PoTX administration, the area, rise time and half decay time of MEPPs gradually decreased, reaching steady values after 15-20 min. The alteration of the area, rise time and half decay time of EPPs after PoTX application was similar to that observed for MEPPs. We conclude that PoTX affects neuromuscular transmission in rat tissue, and suggest that PoTX could exert both pre- and postsynaptic effects.

Słowa kluczowe

EN

miniature endplate potential; neuromuscular transmission; neuropeptide; ponerine ant; ant; Paroponera clavata; poneratoxin; rat

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2002
• Tom: 07
• Numer: 2
• Opis fizyczny: p.195-202,fig.

Twórcy

autor

Hendrich A B

• Wroclaw Medical University, T.Chalubinskiego 10, 50-368 Wroclaw, Poland

autor

Mozrzymas J.W.

autor

Konopinska D.

autor

Scuka M.

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