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2009 | 58 | 1 |
Tytuł artykułu

Antibacterial study of the medium chain fatty acids and their 1-monoglycerides: individual effects and synergistic relationships

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The antibacterial activity of the medium chain fatty acids and their 1-monoglycerides was evaluated towards several Gram-positive strains belonging to the genera Staphylococcus, Corynebacterium, Bacillus, Listeria and Streptococcus. The 1 -monoglycerides were more active than the fatty acids with monolaurin being the most active compound. Interesting effects were observed when the streptococcal strain Streptococcus pyogenes was used as a test microorganism. First, blocking of the hydroxyl groups of the glycerol moiety of monolaurin led to a compound with remarkable antibacterial activity (MIC, 3.9 μg/ml). Secondly, synergistic relationships were observed between monolaurin and monocaprin as well as between monolaurin and the poorly active lauric acid when their two component mixtures were examined. The mixtures in which one of the components was 2-fold more predominant than the other one were much more active than the pure components taken individually. Moreover, the presence of the components in ratio 1:1 was disadvantageous. Synergistic relationships were also found between monolaurin and monomyristin towards Staphylococcus aureus 209 when monomyristin was in the same quantity as monolaurin or in shortage.
Wydawca
-
Rocznik
Tom
58
Numer
1
Opis fizyczny
p.43-47,fig.,ref.
Twórcy
autor
  • Bulgarian Academy of Sciences, Acad.G.Bonchev Str.Bl.9, 1113 Sofia, Bulgaria
Bibliografia
  • Batovska D., S. Tsubota, Y. Kato, Y. Asano and M. Ubukata. 2004. Lipase-mediated desymmetrization of glycerol with aromatic and aliphatic anhydrides. Tetrahedron Asymm. 15: 3551-3559.
  • Bergsson G., J. Arnfinnsson, O. Steingrimsson and H. Thormar. 2001. In vitro killing of Candida albicans by fatty acids and monoglycerides. Antimicrob. Agents Chemother. 45: 3209-3212.
  • Isaacs C.E. 2005. Human milk inactivates pathogens individually, additively, and synergistically. J. Nutr. 135: 1286-1288.
  • Issacs C., R. Litov and H. Thormar. 1995. Antimicrobal activity of lipids added to human milk, infant formula, and bovine milk. J. Nutr. Biochem. 6: 362-366.
  • Marshall D.L. 1998. Antimicrobial properties of the multifunctional ingredient monolaurin. Abstracts of International Conference of Food System Functionality. Atlanta, GA. USA. p. 31.
  • Nair M., J. Joy, P. Vasudevan, L. Hinckley and T. Hoagland. 2005. Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens. J. Dairy Sci. 88: 3488-3495.
  • Online laboratory manual. 2000. http://www.life.umd.edu/classroom/bsci424/LabMaterialsMethods/BrothTubeMIC.htm.
  • Petshow B., R. Batcma and L. Ford. 1996. Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids. Antimicrob. Agents Chemother. 40: 302-306.
  • Preuss H., B. Echard, M. Enig, I. Brook and T. Elliott. 2005. Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria. Mol. Cell Biochem. 272: 29-34.
  • Rouse M., M. Rotger, K. Piper, J. Steckelberg, M. Scholz, J. Andrews and R. Patel. 2005. In vitro and mi vivo evaluations of the activities of lauric acid monoester fonnulations against Staphylococcus aureus. Antimicrob. Agents Chemother. 49: 3187-3191.
  • Ruzin A. and R. Novick. 1998. Glycerol monolaurate inhibits induction of vancomycin resistance in Enterococcus faecalis. J. Bacteriol. 180: 182-185.
  • Ruzin A. and R. Novick. 2000. Equivalence of lauric acid and glycerol monolaurate as inhibitors of signal transduction in Staphylococcus aureus. J. Bacteriol. 182: 2668-2671.
  • Spooner F. and G. Sykes. 1979. Laboratory assessment of antibacterial activity, pp. 216-217. In: Norris J.R. and D.W. Ribbons (eds). Methods in Microbiology 7B. Academic Press, London.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-article-58d40e28-85f1-48e4-a77a-71aca807f886
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