An investigation of CRK protein kinases of Leishmania and the assessment of their potential as drug targets

• Autorzy: Ali N O , Ibrahim M.E. , Aradaib I.E. , Grant K.M. , Mottram J.C.
• Języki publikacji: EN

Słowa kluczowe

EN

Leishmania donovani; leishmaniasis; cyclin-dependent kinase; eukaryotic cell; Leishmania mexicana; drug target; parasitology; protein kinase

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 2A
• Opis fizyczny: p.571-572

Twórcy

autor

Ali N O

• University of Khartoum, Sudan

autor

Ibrahim M.E.

autor

Aradaib I.E.

autor

Grant K.M.

autor

Mottram J.C.

Bibliografia

• 1. Pines, J. Cyclins and cyclin-dependent kinases: A biochemical view. Biochem. J. 308 (1995) 697-711.
• 2. Brown, L., Hines, J.C. and Ray, D.S. The Crithidia fasciculata CRK gene encodes a novel cdc2-related protein containing large inserts between highly conserved domains. Nucleic Acids Res. 20 (1992) 5451-5456.
• 3. Goméz, E.B., Kornblihtt, A.R. and Tellez-Inon, M.T. Cloning of a cdc2- related protein kinase from Trypanosoma cruzi that interacts with mammalian cyclins. Mol. Biochem. Parasitol. 91 (1998) 337-351.
• 4. Grant, K.M., Hassan, P., Anderson, J.S. and Mottram, J.C. The crk3 gene of Leishmania mexicana encodes a stage-regulated cdc2-related histone H1 kinase that associates with p12cks1. J. Biol. Chem. 273 (1998) 10153-10159.
• 5. Mottram, J.C., Kinnaird, J., Shiels, B.R., Tait, A. and Barry, J.D. A novel CDC2-related protein kinase from Leishmania mexicana, Lmmcrkl, is post-translationally regulated during the life-cycle. J. Biol. Chem. 268 (1993) 21044-21051.
• 6. Wang, Y., Dimitrov, K., Garrity, L.K., Sazer, S. and Beverley, S.M. Stage-specific activity of the Leishmania major CRK3 kinase and functional rescue of a Schizosaccharomyces pombe cdc2 mutant. Mol. Biochem. Parasitol. 96 (1998) 139-150.
• 7. Hassan, P., Fergusson, D., Grant, K.M. and Mottram, J.C. The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana. Mol. Biochem. Parasitol. 113 (2001) 189-198.