Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein

• Autorzy: Olejnik-Schmidt A K , Schmidt M.T. , Gozdzicka-Jozefiak A.
• Języki publikacji: EN

Abstrakty

EN

The human NR4A1 orphan receptor is a member of the TR3 steroid receptor superfamily, which binds DNA at the NBRE and NurRE responsive elements. The TR3 receptors are involved in the regulation of differentiation, proliferation and apoptosis. We report that NR4A1 interacts with human papillomavirus type 16 (HPV16) E2 protein — a key papillomavirus regulatory factor. This interaction might be involved in the transcription regulation of the HPV16 genes and the regulation of infected cell homeostasis.

Słowa kluczowe

EN

two-hybrid system; ligand; transcription factor; cell cytoplasm; cellular homeostasis; orphan receptor; nuclear localization; endocrine hormone receptor; protein; HPV16 gene; nucleus

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2006
• Tom: 11
• Numer: 1
• Opis fizyczny: p.102-108,fig.,ref.

Twórcy

autor

Olejnik-Schmidt A K

• August Cieszkowski University of Agriculture, Wojska Polskiego 48, 60-627 Poznan, Poland

autor

Schmidt M.T.

autor

Gozdzicka-Jozefiak A.

Bibliografia

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