Monocytes in children with leukemias and lymphomas - down-regulation of HLA and costimulatory molecules

• Autorzy: Luczynski W. , Stasiak-Barmuta A. , Krawczuk-Rybak M. , Szymanski M. , Malinowska I. , Mitura-Lesiuk M.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to evaluate the function of monocytes in children with leukemias and lymphomas based on the expression of critical costimulatory, activatory and adhesion molecules (CD80, CD86, HLA-DR and CD54 = ICAM-1), esti­mated with tricolor flow cytometry. In comparison to the control group we found a lower percentage of monocytes with costimulatory molecules (CD80 before and CD86 after lipopolysaccharide stimulation) at the time of diagnosis and of monocytes with HLA-DR molecules after remission induction. We also noted a lower percentage of monocytes with HLA-DR expression in the group with severe or ther­apy resistant infections. The results of our investigation suggest some defect in costimulation and antigen presentation in lymphoproliferative diseases in children.

Słowa kluczowe

EN

lymphoma; human leucocyte antigen; infection; costimulatory molecule; leukemia; monocyte; child

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 4
• Opis fizyczny: p.1067-1073,fig.,ref.

Twórcy

autor

Luczynski W.

• Medical University of Bialystok, G.Waszyngtona 17, 15-274 Bialystok, Poland

autor

Stasiak-Barmuta A.

autor

Krawczuk-Rybak M.

autor

Szymanski M.

autor

Malinowska I.

autor

Mitura-Lesiuk M.

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