Receptory metabotropowe glutaminianergicze [mGluR] w procesach ostrego bolu

• Autorzy: Kania B F , Kwapisiewicz M.

Warianty tytułu

EN

Metabotropic glutamate receptors in the acute pain

• Języki publikacji: PL

Abstrakty

EN

The paper reviews the molecular structure, distribution and the role of metabotropic glutamate receptors (mGluRs) as excitatory aminoacid receptors. These receptors comprise a family which consists of at least eight members (mGluR₁₋₈) and coupled to various intracellular second messenger systems through G-proteins. These receptors mediate the neuromodulatory action of glutamate, and have been traditionally divided into three main groups (mGluR I, II i III) based on sequence similarity. Recent progress in the development of specific antagonists (LY 367 385, MPEP for mGluR₁) and/or agonist LY 354740, ADPC for mGluR₂⁄₃ and L-AP4 for mGluR₄) for these receptors can significantly facilitate the prophilaxy and therapy of different types of pain.

Słowa kluczowe

PL

ssaki; bol; bole ostre; receptory metabotropowe glutaminianergiczne; budowa molekularna; klasyfikacja; lokalizacja; agonisci receptorow metabotropowych glutaminianergicznych; antagonisci receptorow metabotropowych glutaminianergicznych; mechanizm dzialania

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2008
• Tom: 64
• Numer: 07
• Opis fizyczny: s.866-871,rys.,tab.,bibliogr.

Twórcy

autor

Kania B F

• Szkola Glowna Gospodarstwa Wiejskiego, ul.Nowoursynowska 159, 02-787 Warszawa

autor

Kwapisiewicz M.

Bibliografia

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