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2008 | 64 | 05 |

Tytuł artykułu

Czynnik transkrypcyjny STAT5A a cechy uzytkowe bydla

Warianty tytułu

EN
STAT5A transcription factor with reference to production traits in cattle

Języki publikacji

PL

Abstrakty

EN
STATs (signal transducers and activators of transcription) are latent transcription factors present in the cytoplasm of the majority of animal cells. They are activated by tyrosine phosphorylation and then translocated to the nucleus where they induce transcription of target genes. The STAT5A factor mediates the actions of cytokines and peptide hormones, including prolactin and growth hormone. STAT5A, previously known as MGF (mammary gland factor), is the most important transcription factor mediating the action of ligands on the expression of genes responsible for production traits in cattle.

Wydawca

-

Rocznik

Tom

64

Numer

05

Opis fizyczny

s.632-634,tab.,bibliogr.

Twórcy

autor
  • Akademia Rolnicza w Szczecinie, ul.Doktora Judyma 6, 71-460 Szczecin
autor
autor

Bibliografia

  • 1. Antoniou E., Hirts B. J., Grosz M., Skidmore C. J.: A single strand conformation polymorphism in the bovine gene STAT5A. Anim. Genet. 1999, 30, 225-244.
  • 2. Benekli M., Maria R. B., Baumann H., Wetzler M.: Signal transducer and activator of transcription proteins in leukemias. Blood 2003, 101, 2940-2954.
  • 3. Brym P., Kamiński S., Ruść A.: New SSCP polymorphism within bovine STAT5A gene and its associations with milk performance traits in Black-and-White and Jersey cattle. J. Appl. Genet. 2004, 45, 445-452.
  • 4. Darnell J. E. Jr.: STATs and gene regulation. Science 1997, 277, 1630-1635.
  • 5. Flisikowski K., Oprządek J., Dymnicki E., Zwierzchowski L.: New polymorphism in bovine STAT5A gene and its association with meat production traits in beef cattle. Anim. Sci. Pap. Rep. 2003b, 21, 147-157.
  • 6. Flisikowski K., Szymanowska M., Zwierzchowski L.: The DNA binding capacity of genetic variants of the bovine STAT5A transcription factor. Cell. Mole. Biol. Lett. 2003a, 8, 831-840.
  • 7. Flisikowski K., Starzyński R. R., Zwierzchowski L.: Promoter variant - dependent expression of the STAT5A gene in bovine liver. Biochim. Biophys. Acta 2004, 1679, 195-199.
  • 8. Flisikowski K., Zwierzchowski L.: Polymerase chain reaction-heteroduplex (PCR-HD) polymorphism within the bovine STAT5A gene. J. Appl. Genet. 2003, 44, 185-189.
  • 9. Freeman M. E., Kanyicska B., Lerant A., Nagy G.: Prolactin: structure, function and regulation of secretion. Physiolog. Rev. 2000, 80, 1523-1631.
  • 10. Goldammer T., Meyer L., Seyfert H. M., Brunner R. M., Schwerin M.: STAT5A encoding gene maps to chromosome 19 in cattle and goat and chromosome 11 in sheep. Mammal Genome 1997, 8, 705-706.
  • 11. Hendry L., John S.: Regulation of STAT signaling by proteolytic processing. Eur. J. Biochem. 2004, 271, 4613-4620.
  • 12. Iavnilovitch E., Groner B., Barasch I.: Overexpression and Forced Activation of STAT5 in Mammary Gland of Transgenic Mice Promotes Cellular Proliferation, Enhances Differentiation, and Delays Postlactational Apoptosis. Mol. Cancer Res. 2002, 1, 32-47.
  • 13. Ihle J. N.: STATs: Signal transducers and activators of transcription. Cell 1996, 84, 331-334.
  • 14. Joung Y. H., Park J. H., Park T., Lee C. S., Kim O. H., Ye S. H., Yang U. M., Lee K. J., Yang Y. M.: Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells. Exp. Mol. Med. 2003, 35, 350-357.
  • 15. Jove R.: Preface: STAT signaling. Oncogene 2000, 19, 2466-2467.
  • 16. Kazansky A. V., Raught B., Lindsey S. M., Wang Y., Rosen J. M.: Regulation of mammary gland factor/STAT5A during mammary gland development. Mol. Endocrinol. 1995, 9, 1598-1609.
  • 17. Lee H., Dekkers J. C. M., Soller M., Malek M., Fernando R. L.: Application of the false discovery rate to quantitative trait loci interval mapping with multiple traits. Genetics 2002, 161, 905-914.
  • 18. McCracken J. Y., Molenaara J., Snell R. J., Davey H. W., Wilkins R. J.: Polymorphic TG repeats presents within the bovine STAT5A gene. Anim. Genet. 1997, 28, 453-464.
  • 19. Molenaar A., Wheeler T. T., McCracken J. Y., Seyfert H. M.: The STAT 3-encoding gene resides within the 40 kbp gap between the STAT5A- and STAT5B-encoding genes in cattle. Anim. Genet. 2000, 31, 333-346.
  • 20. Nanashima N., Asano J., Hayakari M., Nakamura T., Nakano H., Yamada T., Shimizu T., Akita M., Fan Y., Tsuchida S.: Nuclear localization of STAT5 modified with O - linkedN - acetylglucosamine and early involution in the mammary gland of Hirosaki Hairless Rat. JBC Pap. 2005 (w druku).
  • 21. Rawlings J. S., Rosler K. M., Harrison D. A.: The JAK/STAT signaling pathway. J. Cell Sci. 2004, 117, 1281-1283.
  • 22. Seyfert H., Pitra C., Meyer L., Brunner R. M., Wheeler T. T., Molenaara A., McCracken J. Y., Herrmann J., Thiesen H., Schwerin M.: Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains. J. Molec. Evolution 2005, 50, 550-561.
  • 23. Wakao H., Schmitt-Ney M., Groner B.: Mammary Gland-specific Nuclear Factor Is Present in Lactating Rodent and Bovine Mammary Tissue and Composed of a Single Polypeptide of 89 kDa. J. Biol. Chem. 1992, 267, 16365-16370.
  • 24. Wakao H., Gouilleux F., Groner B.: Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 1994, 13, 2182-2191.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-534205f4-f9d6-4f03-b150-8f982ebdcfc6
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