Farmakokinetyka kofeiny u cielat rasy czarno-bialej oraz mieszancow rasy czarno-bialej i holsztynsko-fryzyjskiej

• Autorzy: Janus K , Bartos A. , Kozlowska M. , Suszycki S. , Antoszek J. , Muszczynski Z.

Warianty tytułu

EN

Pharmacokinetics of caffeine in Black-and-White breed and BW x HF cross-breed calves

• Języki publikacji: PL

Abstrakty

EN

The aim of this study was to compare of pharmacokinetics of caffeine in calves of the Black-and-White (BW) breed and cross-breed Black-and-White x Holstein-Friesian (BW x HF (50% HF)) calves. The effect of age on “interbreed” differences in the values of selected pharmacokinetic parameters of this model drug was examined. The experiment was carried out on 20 healthy calves: 10 of BW breed and 10 cross-breed. The caffeine test was performed in calves aged 10, 20 and 40-days-of-life. The animals received caffeine per os at a dose of 5 mg/kg body weight. The concentration of caffeine in the plasma was determined by the EMIT (enzyme-multiplied immunoassay technique) method. The pharmacokinetics of caffeine were calculated through a non-compartmental method, using The TopFit computer software. The obtained results indicate that the age of calves had an influence on the values of pharmacokinetic parameters of caffeine. We observed that estimated pharmacokinetic parameters of caffeine differed significantly between 10, 20 and 40-day-old calves (P < 0.05; P < 0.01). Moreover, it was stated that pharmacokinetic parameters of caffeine in Black-and-White and 50% HF cross-breed calves do not differ significantly.

Słowa kluczowe

PL

bydlo; farmakokinetyka; bydlo czarno-biale; bydlo holsztynsko-fryzyjskie; kofeina; mieszance; cieleta

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 06
• Opis fizyczny: s.696-699,tab.,bibliogr.

Twórcy

autor

Janus K

• Akademia Rolnicza w Szczecinie, ul.Doktora Judyma 2, 71-466 Szczecin

autor

Bartos A.

autor

Kozlowska M.

autor

Suszycki S.

autor

Antoszek J.

autor

Muszczynski Z.

Bibliografia

• 1. Aldridge A., Aranda J. V., Neims A. H.: Caffeine metabolism in the newborn. Clin. Pharmacol. Ther. 1999, 25, 447-453.
• 2. Aramaki S., Suzuki E., Ishidaka O.: Pharmacokinetics of caffeine and its metabolites in horses after intravenous, intramuscular or oral administration. Chem. Pharm. Bull. 1991, 39, 2999-3002.
• 3. Aranda J. V., Collinge J. M., Zinman R., Waters G.: Maturation of caffeine in infancy. Arch. Dis. Childh. 1999, 54, 946-949.
• 4. Bechtel Y. C., Bechter P. R., Lelouet H., Choisy H., Dy N. R.: The acetylator polymorphism in a Khmer population: clinical consequences. Therapie 2001, 56, 409-413.
• 5. Biederbick W., Joseph G., Rump A., Theisohn M., Klaus W.: Caffeine in saliva after peroral intake: early sample collection as a possible source of error. Ther. Drug Monit. 1997, 19, 521-524.
• 6. Boothe D. M., Cullen J. M., Calvin J. A., Jenkins W. L., Brown S. A., Green R. A., Corrier D. E.: Antipyrine and caffeine disposition in clinically normal dogs and dogs with progressive liver disease. Am. J. Vet. Res. 1994, 55, 254-261.
• 7. Danielson T. J., Golsteyn L. R.: Systemic clearance and demethylation of caffeine in sheep and cattle. Drug Metab. Disp. 1996, 24, 1058-1061.
• 8. De Graves F. J., Ruffin D. C., Duran S. H., Spano J. S., Whatley E. M., Schumacher J., Riddell M. G.: Pharmacokinetics of caffeine in lactating dairy cows. Am. J. Vet. Res. 1995, 56, 619-622.
• 9. Falcao A. C., Fernandez de Gatta M. M., Delgado M. F., Santos Buelga D., Garcia M. J., Dominguez-Gil A., Lanao J. M.: Population pharmacokinetics of caffeine in premature neonates. Eur. J. Clin. Pharmacol. 1997, 52, 211-217.
• 10. Grochowina B., Janus K.: Farmakokinetyka paracetamolu u cieląt rasy cb oraz mieszańców cb × hf. Medycyna Wet. 2006, 62 (w druku).
• 11. Grochowina B., Janus K.: Farmakokinetyka paracetamolu w osoczu krwi i ślinie u cieląt. Medycyna Wet. 2006, 62, 686-689.
• 12. Grochowina B., Janus K.: Wpływ wieku na farmakokinetykę paracetamolu u cieląt. Medycyna Wet. 2006, 62, 193-196.
• 13. Janus K., Antoszek J., Suszycki S.: The effect of short-term starvation or water deprivation on caffeine pharmacokinetics in calves. Res. Vet. Sci. 2001, 70, 109-113.
• 14. Janus K., Grochowina B., Antoszek J., Suszycki S., Muszczynski Z.: The effect of food or water deprivation on paracetamol pharmacokinetics in calves. J. Vet. Pharmacol. Ther. 2003, 26, 291-296.
• 15. Kalow W., Tang B. K.: The use of caffeine for enzyme assays: A critical appraisal. Clin. Pharmacol. Ther. 1993, 53, 503-514.
• 16. Kearns G. L., Reed M. D.: Clinical pharmacokinetics in infants and children, a reppraisal. Clin. Pharmacokinet. 1999, 17, 29-52.
• 17. Klinger W.: Biotransformation of drugs and other xenobiotics during postnatal development. Pharmacol. Therap. 1998, 16, 377-400.
• 18. Monshouwer M., Witkamp R. F., Nijmeijer S. M., Pijper S. A., Verheijden J. H. M., Van Miert A. S. J. P. A. M.: Selective effects of bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol and indocyanine green in the pig. Xenobiotica. 1995, 25, 491-499.
• 19. Morselli P. L.: Clinical pharmacology of the perinatal period and early infancy. Clin. Pharmacokinet. 1999, 17, 13-35.
• 20. Newton R., Broughton L. J., Lind M. J., Morrison P. J., Rogers H. J., Brodbrok I. D.: Plasma and saliva pharmacokinetics of caffeine in man. Eur J. Clin. Pharmacol. 2001, 21, 45-51.
• 21. Notarianni L. J., Dobrocky P., Godlewski G., Jones R. W., Bennett P. N.: Caffeine as a metabolic probe: NAT2 phenotyping. Br. J. Clin. Pharmacol. 1996, 41, 169-173.
• 22. Pastera J., Anzenbacher P., Fiala Z.: Phenotyping of cytochrome P450 1A2 and N-acetyltransferase (NAT2) using in the vivo caffeine test as a tool for determining individual susceptibility to selected xenobiotics. Acta Med. 1999, 42, 3-5.
• 23. Peck K., Mealey K. L., Matthews N. S., Taylor T. S.: Comparative pharmacokinetics of caffeine and three metabolites in clinically normal horses and donkeys. Am. J. Vet. Res. 1997, 58, 881-884.
• 24. Schumacher J., Spano J. S., Wilson R. C.: Caffeine clearance in the horse. Vet. Res. Commun. 1994, 18, 367-372.
• 25. Spigset O., Hagg S., Soderstrom E., Dahlquist R.: The paraxanthine/caffeine ratio in serum or in saliva as a measure of CYP1A2 activity - when should the sample be obtained? Pharmacogenetics 1999, 9, 409-412.
• 26. Tang B., Kadar D., Qian L.: Caffeine as a metabolic probe: Validation of its use for acetylator phenotyping. Clin. Pharmacol. Ther. 2001, 49, 648-654.
• 27. Tantcheva-Poor I., Zaigler M., Rietbrock S., Fuhr U.: Estimation of cytochrome P450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test. Pharmacogenetics 1999, 9, 131-144.
• 28. Todi F., Mendonca M., Ryan M., Herskovits P.: The confirmation and control of metabolic caffeine in standardbred horses after administration of theophylline. J. Vet. Pharmacol. Ther. 1999, 22, 333-342.
• 29. Varagnolo M., Plebani M., Mussap M., Nemetz L., Paleari C. D., Burlina A.: Caffeine as a indicator of metabolic functions of microsomal liver enzymes. Clin. Chim. Acta 1998, 183, 91-94.
• 30. Warszawski D., Gorodischer R., Moses S. W.: Caffeine pharmacokinetics in young and adult dogs. Biol. Neonate 1997, 32, 138-142.
• 31. Wasfi I. A., Elghazali M., Boni N. S., Hadi A. A. A., Alhadrami G. A., Almuhrami A. M., Alkatheeri N. A., Barezaiq I. M., Agha B. A. O., Wajid S. A.: The disposition of theophylline in camels after intravenous administration. J. Vet. Pharmacol. Ther. 1999, 22, 255-260.
• 32. Wasfi I. A., Boni N. S., Elghazali M., Abdel Hadi A. A., Almuhrami A. M., Barezaig I. M., Alkatheeri N. A.: The pharmacokinetics, metabolism and urinary detection time of caffeine in camels. Res. Vet. Sci. 2000, 69, 69-74.
• 33. Ziebell J., Shaw-Stiffel T.: Update on the use of metabolic probes to quantify liver function - caffeine versus lidocaine. Dig. Dis. 1995, 13, 239-250.
• 34. Zweers-Zeilmaker W. M., Batzias J., Maas R. F. M., Horbach G. J., Van Miert A. S. J. P. A. M., Witkamp R. F.: In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (caprus hircus aegagrus): substrate activities and effect of inducers. Xenobiotica 1996, 26, 1131-1141.
• 35. Zylber-Katz E., Granit L., Levy M.: Relationship between caffeine concentrations in plasma and saliva. Clin. Pharmacol. Ther. 1994, 36, 133-137.