Przydatnosc oznaczania gradientu stezen bialka calkowitego i albumin w plynie i surowicy krwi psow w roznicowaniu przesiekow i wysiekow

• Autorzy: Glinska K , Nicpon J. , Simon K.

Warianty tytułu

EN

Value of serum-ascites total protein gradient and serum-ascites albumin gradient in the diversification of exudates and transudates

• Języki publikacji: PL

Abstrakty

EN

The aim of the study was to determine the effectiveness of total protein (AFTP), serum-ascites total protein gradient, and serum-ascites albumin gradient (SAAG) determination for the diagnostics of ascites in dogs. The examinations were conducted on 68 dogs of both sexes and different breeds, aged 5 months to 12 years, manifesting signs of ascites. All the animals underwent ECG, abdominal USG, blood testing (total protein, albumin). The concentration of total protein, albumin and leukocyte count was additionally determined in the ascites fluid. On the basis of the obtained results the dogs were divided into 3 groups depending on the disease etiology: group 1 - 38 dogs with the signs of ascites connected with cardiac insufficiency, group 2 - 23 dogs with the signs of ascites connected with neoplastic diseases, group 3 - 7 dogs with the signs of ascites connected with liver parenchyma pathology. The statistical analysis of the obtained results showed statistically significant differences between 3 examined groups in total protein concentration in ascites fluid (p=0.001), serum-ascites total protein gradient (p=0.003) and serum-ascites albumin gradient (p=0.0027). The determination of the serum-ascites total protein gradient and serum-ascites albumin gradient is a useful diagnostic test in the diversification of transudes and exudates. The serum-ascites total protein gradient and serum-ascites albumin gradient is significantly lower in the group of dogs with liver disease than in the group with cardiac insufficiency and neoplastic diseases. The serum-ascites albumin gradient is useful as a marker for portal hypertension.

Słowa kluczowe

PL

psy; plyn z jamy otrzewnej; przesiek; wysiek; roznicowanie; surowica krwi; bialko calkowite; albuminy; stezenie bialek; gradient stezenia; oznaczanie

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2008
• Tom: 64
• Numer: 10
• Opis fizyczny: s.1232-1236,rys.,bibliogr.

Twórcy

autor

Glinska K

• Uniwersytet Przyrodniczy we Wroclawiu, pl.Grunwaldzki 47, 50-366 Wroclaw

autor

Nicpon J.

autor

Simon K.

Bibliografia

• 1.Akriviadis E. A., Kapnias D., Hadjigavriel M., Mitsiou A., Goulis J.: Serum/ ascites albumin gradient: its value as a rational approach to the differential diagnosis of ascites. Scand. J. Gastroenterol. 1997, 32, 736.
• 2.Alba D., Torres E., Vazquez J. J.: Sero-ascitic gradient of albumin: usefulness and diagnostic limitations An. Med. Intern. 1995, 12, 404-407.
• 3.Bansal S., Kaur K., Bansal A. K.: Diagnosing ascitic etiology on a biochemical basis. Hepatogastroenterology 1998, 45, 1673-1677.
• 4.Dittrich S., Yordi L. M., de Mattos A. A.: The value of serum-ascites albumin gradient for the determination of portal hypertension in the diagnosis of ascites. Hepatogastroenterology 2001, 48, 166-168.
• 5.Fry M. M., DeCock H. E., Greeley M. A., Vernau W.: Abdominal fluid from a dog. Vet. Clin. Pathol. 2003, 32, 77-80.
• 6.Goyal A. K., Goyal S. K., Pokharna D. S., Sharma S. K.: Differential diagnosis of ascitic fluid: evaluation and comparison of various biochemical criteria with a special reference to serum ascites albumin concentration gradient and its relation to portal pressure. Trop. Gastroenterol. 1989, 10, 51-55.
• 7.Gupta R., Misra S. P., Dwivedi M., Misra V., Kumar S., Gupta S. C.: Diagnosing ascites: value of ascitic fluid total protein, albumin, cholesterol, their ratios, serum-ascites albumin and cholesterol gradient. Gastroenterol. Hepatol. 1995, 10, 295-299.
• 8.Hoefs J. C.: Serum protein concentration and portal pressure determine the ascites fluid protein concentration in patients with chronic liver disease. J. Lab. Clin. Med. 1983, 102, 260-273. 9.Laudanno O. M., Bresciani P., Silva M.: Diagnostic efficacy of albumin gradient in different causes of ascitis. Acta Gastroenterol. Latinoam. 1995, 25, 285-290.
• 10.MacMathuna P. M.: Mechanisms and consequences of portal hypertension.
• 11.Paddock F. K.: The diagnostic significance of serum fluid in disease. N. Engl. J. Med. 1940, 223, 1010-1005.
• 12.Pare P., Talbot J., Hoefs J. C.: Serum-ascites albumin concentration gradient: a physiologic approach to the differential diagnosis of ascites. Gastroenterology 1983, 85, 240-144. 13.Pembleton-Corbett J. R., Center S. A., Schermerhorn T., Yeager A. E., Erb H. N.: Serum-effusion albumin gradient in dogs with transudative abdominal effusion. J. Vet. Intern. Med. 2000, 14, 613-618.
• 14.Runyon B. A., Montano A. A., Akriviadis E. A.: The serum-ascites albumin gradient in the differential diagnosis of ascites is superior to the exudatetransudate concept. Ann. Intern. Med. 1992, 117, 215-220.
• 15.Runyon B. A., Montano A. A., Akriviadis E. A., Antillon M. R., Irving M. A., McHutchison J. G.: The serum-ascites albumin gradient is superior to the exudate-transudate concept in the differential diagnosis of ascites. Ann. Intern. Med. 1992, 117, 215-220.
• 16.Satz N.: Laboratory chemical analysis in ascites. Schweiz. Med. Wochenschr. 1991, 121, 536-547.
• 17.Valdivia R. M., Llanos C. A., Zapata S. C., Munoz O. N.: The validity of the proteins concentrations in the ascitic liquid and serum for the differential diagnosis of the ascetic. Rev. Gastroenterol Peru. 2002, 22, 279-286.
• 18.Zhu X. H., Liu B., Cheng Z. Y.: Diagnostic value of serum-ascites albumin gradient. Hunan. Yi Ke Da Xue Xue Bao. 2003, 28, 278-280.