Immunosupresja jako przyczyna chorob swin o etiologii wieloczynnikowej

• Autorzy: Truszczynski M , Pejsak Z.

Warianty tytułu

EN

Immunosuppression as the cause of swine diseases of multifactorial etiology

• Języki publikacji: PL

Abstrakty

EN

After presenting the definition of immunosuppression the paper concentrates on the immunosuppressive properties of porcine circovirus type 2 (PCV2). Its role in the etiology of the post-weaning multisystemic wasting syndrome (PMWS) and the other porcine circovirus diseases (PCVD) is characterized, indicating that following the immunosuppressive action of PCV2 facultatively pathogenic microorganisms join the etiology of the disease syndrome which becomes multifactorial. The lymphocytopenia resulting from PCV2 infection is particularly manifest among the B lymphocytes, followed by the T lymphocytes. In vivo analyses have shown that PCV2 is most frequently associated with monocytes, macrophages and dendritic cells (DC). PCV2 infection of macrophages and DCs is the key factor determining the consequences for immune defense competence. The differences between conventional DCs (cDCs) and plasmacytoid DCs (pDCs) are mentioned. The term cDCs defines cells with antigen presenting functions and the term pDCs represents the interferon, type 1 producing cells. Examples of immunosuppressive action of other pathogens have been presented. Classical swine fever virus inhibits the interferon production in the infected DCs. In addition it causes leucopenia. These changes enablr opportunistic Pasteurella multocida and Streptococcus sp. strains to cause septicemia in the infected pigs. Immunosuppressive action of pseudorabies virus is mentioned resulting in secondary infection by other species of viruses or bacteria. Moreover, as presented in the paper, porcine reproductive and respiratory syndrome virus demonstrates immunosuppressive properties.

Słowa kluczowe

PL

trzoda chlewna; immunosupresja; choroby zwierzat; etiologia; choroby wieloczynnikowe; wirus PCV-2

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2010
• Tom: 66
• Numer: 06
• Opis fizyczny: s.370-373,bibliogr.

Twórcy

autor

Truszczynski M

• Panstwowy Instytut Weterynaryjny - Panstwowy Instytut Badawczy, Al.Partyzantow 57, 24-100 Pulawy

autor

Pejsak Z.

Bibliografia

• 1.Anon.: Zakaźne zapalenie torby Fabrycjusza (IBD). Materiały z konferencji naukowej PIWet-PIB, Puławy 2001.
• 2.Berg T. van den: Acute infectious bursal disease in poultry: a review. Avian Pathol. 2000, 29, 175-194.
• 3.Brukman A., Enquist L. W.: Suppression of the interferon-mediated innate immune response by Pseudorabies virus. Journal Virol. 2006, 80, 6345-6356.
• 4.Buddaert W., Van Reeth K., Pensaert M.: In vivo and in vitro interferon (IFN) studies with the porcine reproductive and respiratory syndrome virus (PRRSV). Adv. Exp. Med. Biol. 1998, 440, 461-467.
• 5.Chang H.-W., Jeng C.-R., Lin T.-L., Liu J. I., Chiou M.-T., Tsai Y.-C., Chia M.-Y., Jan T.-R., Pang V. F.: Immunopathological effects of porcine circovirus type 2 (PCV2) on swine alveolar macrophages by in vitro inoculation. Vet. Immunol. Immunopathol. 2006, 110, 207-219.
• 6.Charerntantanakul W.: Evidence for immunosuppressive properties of porcine reproductive and respiratory syndrome virus. Veterinary Journal 2007, 5, 17-28.
• 7.Chinsakchai S., Molitor T. W.: Immunobiology of pseudorabies virus infection in swine. Vet. Immunol. Immunopathol. 1994, 43, 107-116.
• 8.Chiou M. T., Jeng C. R., Chueh L. L., Cheng C. H., Pang V. F.: Effects of porcine reproductive and respiratory syndrome virus (isolate tw91) on porcine alveolar macrophages in vitro. Vet. Microbiol. 2000, 71, 9-25.
• 9.Chitko-McKown C. G., Blecha F.: Pulmonary intravascular macrophages: a review of immune properties and functions. Ann. Rech. Vet. 1992, 23, 201-214.
• 10.Done S. H., Paton D. J.: Porcine reproductive and respiratory syndrome: clinical disease, pathology and immunosuppression. Vet. Rec. 1996, 136, 32-35.
• 11.Ellis J., Clark E., Haines D., West K., Krakowka S., Kennedy S., Allan G. M.: Porcine circovirus-2 and concurrent infections in the field. Vet. Microbiol. 2004, 98, 159-163.
• 12.Gaciong Z., Korczak-Kowalska G.: Immunologia transplantacyjna, [w:] Gołąb J., Jakóbisiak M., Lasek W.: Immunologia. Wyd. Naukowe PWN, Warszawa 2006, 493-521.
• 13.Galina L., Pijoan C., Sitjar M., Christianson W. T., Rossow K., Collins J. E.: Interaction between Streptococcus suis serotype 2 and porcine reproductive and respiratory syndrome virus in specific pathogen-free piglets. Vet. Rec. 1994, 134, 60-64.
• 14.Kayser F. H., Bienz K. A., Eckert J., Zinkernagel R. M.: Mikrobiologia lekarska. Wydawnictwo Lekarskie PZWL, Warszawa 2007.
• 15.Kekarainen T., Montoya M., Mateu E., Segalés J.: Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses. J. General Virology 2008, 89, 760-765.
• 16.McCullough K. C., Ruggli N., Summerfield A.: Dendritic cells - At the frontline of pathogen attack. Vet. Immunol. Immunopathol. 2009, 128, 7-15.
• 17.McCullough K. C., Vincent I. E., Summerfield A., Krakowka S., Ellis J. A., Segalés J., Allan G. M.: The immunology of PCV2 infections. American Association of Swine Veterinarians 2007, 497-503.
• 18.Nielsen J., Vincent I. E., Bøtner A., Ladekjær-Mikkelsen A. S., Allan G., Summerfield A., McCullough K. C.: Association of lymphopenia with porcine circovirus type 2 induced postweaning multisystemic wasting syndrome (PMWS). Vet. Immunol. Immunopathol. 2003, 92, 97-111.
• 19.Ruggli N., Tratschin J. D., Schweizer M., McCullough K. C., Hofmann M. A., Summerfield A.: Classical swine fever virus interferes with cellular antiviral defense: evidence for a novel function of Npro. J. Virol. 2003, 77, 7645-7654.
• 20.Segalés J., Allan G. M., Domingo M.: Porcine circovirus diseases. Anim. Health Res. Rev. 2005, 6, 119-142.
• 21.Segalés J., Domingo M., Chianini F., Majó N., Domínguez J., Darwich L., Mateu E.: Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Vet. Microbiol. 2004, 98, 151-158.
• 22.Solano G. I., Segalés J., Collins J. E., Molitor T. W., Pijoan C.: Porcine reproductive and respiratory syndrome virus (PRRSV) interaction with Haemophilus parasuis. Vet. Microbiol. 1997, 55, 247-257.
• 23.Summerfield A., McCullought K. C.: The porcine dendritic cell family. Develop. Comp. Immunol. 2009, 33, 299-309.
• 24.Takashima Y., Matsumoto Y., Otsuka H.: Suppression of the proliferation of mouse splenocytes by Pseudorabies virus. J. Vet. Med. Sci. 2000, 62, 1227-1230.
• 25.Thacker E. L., Halbur P. G., Ross R. F., Thanawongnuwech R., Thacker B. J.: Mycoplasma hyopneumoniae potentiation of PRRSV-induced pneumonia. J. Clin. Microbiol. 1998, 37, 620-627.
• 26.Thanawongnuwech R., Brown G. B., Halbur P. G., Roth J. A., Royer R. I., Thacker B. J.: Pathogenesis of porcine reproductive and respiratory syndrome virus-induced increase in susceptibility to Streptococcus suis infection. Vet. Pathol. 2000, 37, 143-152.
• 27.Truszczyński M., Pejsak Z.: Chorobotwórczość cirkowirusów ze szczególnym uwzględnieniem poodsadzeniowego, wielonarządowego zespołu wyniszczającego świń. Medycyna Wet. 2008, 64, 379-382.
• 28.Truszczyński M., Pejsak Z.: Rola cirkowirusa PCV2 w wywoływaniu zaburzeń w rozrodzie świń. Medycyna Wet. 2009, 65, 6-8.
• 29.Vainio O.: IBDV - induced immunosuppression. Materiały z konferencji naukowej PIWet-PIB, Puławy 2001, s. 23-29.
• 30.Vincent I. E., Carrasco C. P., Guzylack-Piriou L., Herrmann B., McNeilly F., Allan G. M., Summerfield A., McCullough K. C.: Subset-dependent modulation of dendritic cell activity by circovirus type 2. Immunology 2005, 115, 388-398.
• 31.Wills R. W., Fedorka-Cray P. J., Yoon K. J., Gray J. T., Stabel T., Zimmerman J. J.: Synergism between porcine reproductive and respiratory syndrome virus (PRRSV) and Salmonella choleraesuis. Proc. Am. Assoc. Swine Pract. 1997, s. 459-462.