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2009 | 65 | 11 |

Tytuł artykułu

Aktualne dane na temat zakazen wywolywanych przez wirus zapalenia mozgu i miesnia sercowego

Warianty tytułu

EN
Current state of knowledge concerning infections caused by encephalomyocarditis virus

Języki publikacji

PL

Abstrakty

EN
The encephalomyocarditis virus (EMCV) is widespread. It can infect humans and over 30 animal species. Among domestic animals pigs are the most susceptible to infection. The greatest number of EMC outbreaks in Europe were evidenced in Belgium, Italy, Greece and Cyprus. Indeed infections caused by EMCV are common but the clinical course of the disease is infrequent because outbreaks are often clustered in so-called endemic areas. Two philogenetically distinct types of EMCV are known: A - responsible for reproductive disorders and B - causing myocarditis. Some strains are responsible for both types of disorders. In natural conditions pigs are infected with feed or water contaminated by infected rodents' feces. Macrophages play an important role in virus replication and shedding. The tonsils are the gate for the virus entrance. The heart is the target organ for the virus. EMCV causes transplacental infections of embryos and fetuses, resulting either in malformations, abortions and mummifications or the delivery of dead or weak piglets. Neonatal piglets infected by EMCV die without any typical prodromal symptoms; sometimes disorders of the central nervous system are evidenced. In piglets and weaners myocarditis is usually noted. Older pigs usually do not demonstrate the symptoms of the disease. In general EMC is limited to individual farms and single buildings within the farm. In laboratory diagnosis immunohistochemistry, isolation and identification of the virus or its genetic material and serological examinations are used. No specific treatment of EMC is available. In the USA there is a commercial vaccine against EMC but in Europe it is not registered. Because of the role of rodents in the epidemiology of infections the deratization and disinfection of farms is very important.

Wydawca

-

Rocznik

Tom

65

Numer

11

Opis fizyczny

s.747-751,bibliogr.

Twórcy

  • Panstwowy Instytut Weterynaryjny - Panstwowy Instytut Badawczy, Al.Partyzantow 57, 24-100 Pulawy
autor

Bibliografia

  • 1.Bakkali K., Gonzaque M., Boutrouille M., Lipobo-Mbanda A., Cruciere C.: Detection of EMCV in clinical samples by immunomagnetic separation and one step RT-PCR. J. Virol. Meth. 2002, 101, 197-206.
  • 2.Billinis C., Leontides S., Psychas V., Spyrou V., Kostoulas P., Koenen F., Papadopoulos O.: Effect of challenge dose and age in experimental infection of pigs with encephalomyocarditis virus. Vet. Microbiol. 2004, 99, 187-195.
  • 3.Billinis C., Paschaleri-Papadopoulou E., Psychas V., Vlemmas J., Loentides S., Koumbati M., Kyriakis S. C., Papadopoulos O.: Persistence of encephalomyocarditis virus (EMCV) infection in piglets. Vet. Microbiol. 1999, 70, 171-177.
  • 4.Brewer L. A., Lwamba H. C., Murtaugh M. P., Palmenberg A. C., Brown C., Njenga M. K.: Porcine encephalomyocarditis virus persist in pig myocardium and infects human myocardium cells. J. Virol. 2001, 75, 11621-11629.
  • 5.Dea S. A., Bilodeau R., Sauvageau R., Martineau G. P.: Outbreaks in Quebec pig farms of respiratory and reproductive problems associated with encephalomyocarditis virus. J. Vet. Diagn. Invest. 1991, 3, 275-282.
  • 6.Denis P., Liebig H. D., Nowotny N., Billinis C., Papadopoulos O., O'Hara R. S., Knowles N. J., Koenen F.: Genetic variability of encephalomyocarditis virus (EMCV) isolates. Vet. Microbiol. 2006, 113, 1-12.
  • 7.Foni E., Barigazzi G., Sidoli L., Marcato P. S., Sarli G., Della Salda L., Spinaci M.: Experimental encephalomyocarditis virus infection in pigs. J. Vet. Med. B. 1993, 40, 347-352.
  • 8.Gelmetti D., Meroni A., Brocchi E., Koenen F., Cammarata G.: Pathogenesis of encephalomyocarditis experimental infection in young piglets: a potential animal model to study viral myocarditis. Vet. Res. 2006, 37, 15-23.
  • 9.Kluivers M., Maurice H., Vyt P., Koenen F., Nielen M.: Transmission of encephalomyocarditis virus in pigs estimated from field data in Belgium by means of R0. Vet. Res. 1996, 37, 757-766.
  • 10.Knowles N. J., Dickinson N. D., Wisden G., Carra E., Brocchi E., DeSimone F.: Molecular analysis of encephalomyocarditis viruses isolated from pigs and rodents in Italy. Virus Res. 2000, 57, 53-62.
  • 11.Koenen F.: Encephalomyocarditis virus, [w:] Straw B. E., Zimmerman J. J., D'Allaire S., Taylor D. J.: Diseases of Swine. Blackwell Publishing, Ames, Iowa, USA 2006, s. 331-336.
  • 12.Koenen F., DeClerq K., Lefebvre J., Strobbe R.: Reproductive failure in sows following experimental infection with a Belgian EMCV isolate. Vet. Microbiol. 1994, 39, 111-116.
  • 13.Koenen F., Vanderhallen H., Dickinson N. D., Konwles N. J.: Phylogenetic analysis of European encephalomyocarditis viruses: comparison of two genomic regions. Arch. Virol. 1999, 144, 893-903.
  • 14.LaRue R., Myers S., Brewer L., Shaw D. P., Brown C., Seal B. S., Njenga M. K.: A wild-type porcine encephalomyocarditis virus containing a short poly (C) tract is pathogenic to mice, pigs and cynomolgus macaques. J. Virol. 2003, 77, 9136-9146.
  • 15.Maurice H., Nielen M., Brocchi E., Nowotny N., Kassimi L. B., Billinis C., Loukaides P., O'Hara R. S., Koenen F.: The occurrence of encephalomyocarditis virus (EMCV) in European pigs from 1990 to 2001. Epidemiol. Infect. 2005, 133, 547-557.
  • 16.Maurice H., Nielen M., Vyt Ph., Frankema K., Koenen F.: Factors related to clinical appearence of EMCV at Belgian pig farms. Prev. Vet. Med. 2005, 4, 256.
  • 17.Murname T. G.: Encephalomyocarditis, [w:] Viral zoonozes. G. W. Beran (wyd.). CRC Press, Boca Raton 1981, 137-147.
  • 18.Papaioannou N., Billinis C., Psychas V., Papadopoulos O., Vlemmas I.: Pathogenesis of encephalomyocarditis virus (EMCV) infection in piglets during the viraemia phase: a histopatological, immunochistochemical and virological study. J. Comp. Pathol. 2003, 129, 161-168.
  • 19.Paul S., Michiels T.: Cardiovirus leader proteins are functionally interchangeable and have evolved to adapt to virus replication fitness. J. Gen. Virol. 2006, 87, 1237-1246.
  • 20.Psychas V., Papaioannou N., Billinis C., Paschaleri-Papadopoulou E., Leontides S., Papadopolous O., Tsangaris T., Vlemmas J.: Evaluation of ultrastructural changes associated with encephalomyocarditis virus in the myocardium of experimentally infected piglets. Am. J. Vet. Res. 2001, 62, 1653-1657.
  • 21.Spyrou V., Maurice H.: Transmission and pathogenicity of encephalomycarditis virus among rats. Vet. Res. 2004, 35, 113.
  • 22.Vanderhallen H., Koenen F.: Identification of encephalomyocarditis virus in clinical samples by reverse transcription-PCR followed by genetic typing using sequence anaysis. J. Clin. Microbiol. 1998, 36, 3463-3467.
  • 23.Vlemmas J., Billinis C., Psychas V., Papaioannou N., Paschaleri-Papadopoulou E., Leontides S., Papadopoulous O.: Immunohistochemical detection of encephalomyocarditis virus (EMCV) antigen in the heart of experimentally infected piglets. J. Comp. Pathol. 2000, 122, 235-240.
  • 24.Zimmerman J. J., Hill H. T., Beran G. W., Meetz M. C.: Serologic diagnosis of encephalomyocarditis virus infection in swine by the microtiter serum neutralization test. J. Vet. Diagn. Invest. 1990, 2, 347-350.

Typ dokumentu

Bibliografia

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