Effect of long-term aluminium chloride intoxication on selected biochemical parameters and oxidative-antioxidative balance in experimental animals

• Autorzy: Kowalczyk E , Kopff A. , Kedziora J. , Blaszczyk J. , Kopff M. , Niedworok J. , Fijalkowski P.
• Języki publikacji: EN

Abstrakty

EN

Aluminium is numbered among trace elements with a moderate toxic effect on living organisms. We have attempted to assess the influence of long-term aluminium chloride intake on the biochemical parameters and oxidative stress biomarkers in experimental animals. Three months’ administration of aluminium chloride in drinking water at a dose of 80 mg/l significantly elevated blood serum urea and creatinine concentration, as well as oxidative stress biomarkers such as: TBARS content in erythrocytes hemolysate, protein carbonyl groups concentration and 8-hydroxy-2’-deoxyguanosine excretion with urine.

Słowa kluczowe

EN

trace element; grain product; tea leaf; blood serum; nervous system; oxidative stress; food; experimental animal; toxic effect; aluminium; hard cheese; skeletal system; herb; 8-hydroxy-2'-deoxyguanosine; living organism; respiratory system; aluminium chloride; biochemical parameter; biomarker

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2004
• Tom: 13
• Numer: 1
• Opis fizyczny: p.41-43,ref.

Twórcy

autor

Kowalczyk E

• Medical University of Lodz, Pl.Hallera 1, 90-647 Lodz, Poland

autor

Kopff A.

autor

Kedziora J.

autor

Blaszczyk J.

autor

Kopff M.

autor

Niedworok J.

autor

Fijalkowski P.

Bibliografia

• 1. GRACZYK A., RADOMSKA K., DŁUGASZEK M. Synergizm i antagonizm między biopierwiastkami i metalami toksycznymi. Ochrona Środowiska i Zasobów Naturalych nr 18. Instytut Ochrony Środowiska. Warszawa, pp39-45,1999.
• 2. PLIETH C., SATTELMACHER B., HANSEN U.P., KNIGHT M.R. Low-pH-mediated I cytosolic calcium areinhibited by aluminium: a potential mechansm for aluminium toxicity. Plant.J.18 (6), 643,1999.
• 3. AFIFI A. Renal osteodystrophy in developing countries. Artif.Organs. 26 (9), 767, 2002.
• 4. CHEN J., WANG M., RUN D., SHE J. Early chronic aluminium exposure impairs long-term potentaion and depression to the rat dentate gyrus in vivo. Neuroscience,112 (4), 879, 2002.
• 5. CAMPBELL A. The potential role of aluminium in Alzheimers disease. Nephrol.Dial. Transplant. 17,supl 2,17, 2002.
• 6. QITU M.A., RENGEL Z., KUO J. Aluminium toxicity in rye ( Secale cereale): root growth and dynamics of cytoplasmic Ca 2+ in intact root Tipps. Ann. Bot.(London) 89 (2),241, 2002.
• 7. PLATT B., FIDDLER G., RIEDEL G., HENDERSON Z. Aluminium toxicity in the rat brain:histochemical and immunocytochemical evidence. Brain.Res.Bull. 55 (2), 257, 2001.
• 8. EXLEY C., BIRCHALL J.D. The cellurar toxicity of aluminium. J.Theor. Biol 7, 59 (1), 83, 1992.
• 9. ABREO K., GLASS J. Cellurar,biochemical and molecular mechanisms of aluminium toxicity.Nephrol.Dial.Transplant. 8 (1), 5, 1993.
• 10. WARD R.J., ZHANG Y., CRICHTON R.R. Aluminium toxicity and iron homeostasis.; J. Inorg.Biochem. 87 (1-2),9, 2001.
• 11. GRAMICCIONI L., INGRAO G., MILANA M.R., SANTARONI P., TOMASSI G. Aluminium levels in Italian diets and in selected foods from aluminium utensils. Food.Addit.Contam. 13 (7), 767, 1996.
• 12. STARSKA K.Aluminium in food. Rocz.Państw.Zakł.Hig. 44 (1), 55, 1993.
• 13. SEPE A., COSTANTINI S., CIARALLI L., CIPROTTI M., GIORDANO R. Evaluation of aluminium concentration in samples of chocolate and beverages by electrothermal atomic absorption spectrometry. Food.Addit.Contam. 18 (9), 788, 2001.
• 14. Biuletyn Informacyjny Instytutu Leków. Numer Specjalny 3, 1988.
• 15. RICE-EVANS C.A.,DIPLOCK A.T.,SYMONS M.C.R. Techniques in free radicals research. Ed.:Burdon R.H., Knippenberg P.H., Elsevier, Amsterdam,London,New York, Tokyo 1991.
• 16. LEVINE R.L., GARLAND D., OLIVER C.N., AMICI A., CLIMENT J., LENZ A., AHN B., SHALTEIL S., STADTMAN E.R. Determination of carbonyl content of oxidatively modified proteins. Methods. Ensymol. 186, 464, 1990.
• 17. REZNIK A.Z., PACKER L. Oxidative damage to proteins: Spectrophotometric method for carbonyl assay. Methods.Ensymol. 233, 357, 1994.
• 18. WARD R.J., ZHANG Y., CRICHTON R.R. Aluminium toxicity and iron homeostasis. J.Inorg.Biochem. 87 (1-2), 9, 2001.
• 19. FIDOVICH J. The biology of oxygen radicals. Science 201, 875, 1978.
• 20. FORMAN H.J., BOVIES A. Superoxide radical and hydrogen peroxide in mitochondria. In:Pryor W.A.(Ed.) Free Radicals in Biology and Medicine, New York, Acad. Press pp 65-92, 1982.
• 21. DE ZWART L.L., MEERMAN J.H.N., COMMANDEUR J.N.M.,VERMEULEN N.P.E. Biomarkers of free radical damage applications in experimental animals and in humans. Free.Rad. Biol. Med. 26, 202, 1999.
• 22. POPADIUK S., KORZON M., RENKE J., WOŹNIAK M. Carbonyl groups in plasma protein in children with malignant brain tumours. Pol. J.Env.Studies 7, 374, 1998.
• 23. BARTOSZ G. Druga twarz tlenu. PWN,Warszawa, pp17-55,1995.
• 24. MECOCCI P., FANO G., FULLE S., MACGARVEY U.,SHINOBU L., POLIDORI M.C.CHERUBINI A., VECCHIET J., SENIN U., BEAL M.F. Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free. Radic. Biol. Med. 26, 303, 1999.
• 25. MATSUMOYO H.E.,HIRASAWA E., TORIKAI H.,TAKAHASHI E. Localisation of absorbed aluminium in pea root its binding to nucleic acids. Plant Cell.Physiol. 17,127, 1978.
• 26. MORIMURA S., MATSUMOTO H. Effects of aluminium on some properties and template activity of purified pea DNA. Plant.Cell.Physiol. 19, 429, 1978.