Bacterial DNA repair genesn and their eukaryotic homologues: 4. The role of nucleotide excision DNA repair [NER] system in mammalian cells

• Autorzy: Maddukuri L. , Dudzinska D. , Tudek B.
• Języki publikacji: EN

Abstrakty

EN

The eukaryotic cell encounters more than one million various kinds of DNA lesions per day. The nucleotide excision repair (NER) pathway is one of the most important repair mechanisms that removes a wide spectrum of different DNA lesions. NER operates through two sub pathways: global genome repair (GGR) and transcription-coupled repair (TCR). GGR repairs the DNA damage throughout the entire genome and is initiated by the HR23B/XPC complex, while the CSB protein-governed TCR process removes DNA lesions from the actively transcribed strand. The sequence of events and the role of particular NER proteins are currently being extensively discussed. NER proteins also participate in other cellular processes like replication, transcription, chromatin maintenance and protein turnover. Defects in NER underlay severe genetic disorders: xeroderma pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD).

Słowa kluczowe

EN

gene; eukaryotic homologue; DNA repair; nucleotide excision repair system; DNA damage; xeroderma pigmentosum; trichothiodystrophy; mammalian cell; Cockayne syndrome

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2007
• Tom: 54
• Numer: 3
• Opis fizyczny: p.469-482,fig.,ref.

Twórcy

autor

Maddukuri L.

• Polish Academy of Sciences, A.Pawinskiego 5a, 01-106 Warsaw, Poland

autor

Dudzinska D.

autor

Tudek B.

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