On the way to understand biological complexity in plants: S-nutrition as a case study for systems biology

• Autorzy: Hesse H , Hoefgen R.
• Języki publikacji: EN

Abstrakty

EN

The establishment of technologies for high-throughput DNA sequencing (genomics), gene expression (transcriptomics), metabolite and ion analysis (metabolomics/ionomics) and protein analysis (proteomics) carries with it the challenge of processing and interpreting the accumulating data sets. Publicly accessible databases and newly development and adapted bioinformatic tools are employed to mine this data in order to filter relevant correlations and create models describing physiological states. These data allow the reconstruction of networks of interactions of the various cellular components as enzyme activities and complexes, gene expression, metabolite pools or pathway flux modes. Especially when merging information from transcriptomics, metabolomics and proteomics into consistent models, it will be possible to describe and predict the behaviour of biological systems, for example with respect to endogenous or environmental changes. However, to capture the interactions of network elements requires measurements under a variety of conditions to generate or refine existing models. The ultimate goal of systems biology is to understand the molecular principles governing plant responses and consistently explain plant physiology.

Słowa kluczowe

EN

ion analysis; metabolite; DNA sequencing; gene expression; proteome; transcriptome; ionome; protein analysis; biology; sulphur metabolism; metabolome

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2006
• Tom: 11
• Numer: 1
• Opis fizyczny: p.37-55,fig.,ref.

Twórcy

autor

Hesse H

• Max-Planck-Institute fuer Milekulare Pflanzenphysiologie, Am Muehlenberg 1, 14476 Golm, Germany

autor

Hoefgen R.

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