Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions

• Autorzy: Reiter R. J. , Tan D. , Terron M.P. , Flores L.J. , Czarnocki Z.
• Języki publikacji: EN

Abstrakty

EN

This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N-acetyltransferase, which is involved in the production of N-acetylserotonin, the immediate precursor of melatonin, may in fact not always control the quantity of melatonin generated. New evidence from several different laboratories indicates that hydroxyindole-O-methyltransferase, which O-methylates N-acetylserotonin to melatonin may be rate-limiting in some cases. Also, the review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via membrane receptors, nuclear receptors/binding sites and receptor-independent mechanisms, i.e., the direct scavenging of free radicals. Finally, the review briefly summarizes the actions of melatonin and its metabolites in the detoxification of oxygen and nitrogen-based free radicals and related non-radical products. Via these multiple processes, melatonin is capable of influencing the metabolism of every cell in the organism.

Słowa kluczowe

EN

metabolite; nitric oxide synthase; N-acetyltransferase; oxidative stress; glutathione reductase; free radical; antioxidant; glutathione peroxidase; melatonin synthesis; electron donation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2007
• Tom: 54
• Numer: 1
• Opis fizyczny: p.1-9,fig.,ref.

Twórcy

autor

Reiter R. J.

• University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio , TX 78229-3900, USA

autor

Tan D.

autor

Terron M.P.

autor

Flores L.J.

autor

Czarnocki Z.

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