Mice and humans: chromosome engineering and its application to functional genomics

• Autorzy: Klysik J.
• Języki publikacji: EN

Abstrakty

EN

Functional modeling of human genes and diseases requires suitable mammalian model organisms. For its genetic malleability, the mouse is likely to continue to play a major role in defining basic genetic traits and complex pathological disorders. Re­cently, gene targeting techniques have been extended towards developing new engi­neering strategies for generating extensive lesions and rearrangements in mouse chromosomes. While these advances create new opportunities to address similar ab­errations observed in human diseases, they also open new ways of scaling-up mutagensis projects that try to catalogue and annotate cellular functions of mamma­lian genes.

Słowa kluczowe

EN

disease; mice; mammal; human gene; transgenesis; mutagenesis; cell technology; human disease; gene; mouse; man; chromosome engineering; functional genomics

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 3
• Opis fizyczny: p.553-569,fig.

Twórcy

autor

Klysik J.

• Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA

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