Cryptomeria japonica essential oil inhibits the growth of drug-resistant skin pathogens and LPS-induced nitric oxide and pro-inflammatory cytokine production

• Autorzy: Yoon W -J , Kim S.-S. , Oh T.-H. , Lee M.H. , Hyun C.-G.
• Języki publikacji: EN

Abstrakty

EN

In this study, the chemical composition of Cryptomeria japónica essential oil (CJE) was analyzed and its biological activities were tested. CJE was obtained by steam distillation from leaves collected from Jeju Island and analyzed by gas chromatography (GC)-flame ionization detection (FID) and GC-MS. Kaurene (17.20 %), elemol (10.88 %), y-eudesmol (9.41 %), and sabinene (8.86 %) were the major components in CJE. The antibacterial and anti-inflammatory activities of CJE against drug-susceptible and -resistant skin pathogens have been not reported previously. Thus, we determined the anti-bacterial activities of CJE using the disk diffusion method and minimum inhibitory concentration (MIC) values. CJE showed excellent antibacterial activities against Propionibacterium acnes and Staphylococcus epidermidis, which are acne-causing bacteria. The MIC of CJE against drug-susceptible and -resistant P. acens and S. epidermidis ranged from 0.16 to 10.0 μl/ml. In addition, the effects of CJE on nitric oxide (NO), prostaglandin E₂(PGE₂), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were also examined. Pro-inflammatory cytokine and mediator tests indicated that CJE has excellent dose-dependent inhibitory activities. Therefore, based on these results, we propose that CJE is an attractive acne-mitigating candidate for skin health.

Słowa kluczowe

EN

essential oil; chemical composition; skin health; Jeju Island; biological activity; Staphylococcus epidermidis; Propionibacterium acnes; Cryptomeria japonica; skin pathogen; antibacterial activity; cytokine production

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2009
• Tom: 58
• Numer: 1
• Opis fizyczny: p.61-68,fig.,ref.

Twórcy

autor

Yoon W -J

• Research Group for Cosmetic Materials, Jeju Biodiversity Research Institute, Jeju High-Tech Development Institute, Jeju, Korea

autor

Kim S.-S.

autor

Oh T.-H.

autor

Lee M.H.

autor

Hyun C.-G.

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