Plasma membrane rafts and chaperones in cytokine STAT signalling

• Autorzy: Sehgal P. B.
• Języki publikacji: EN

Abstrakty

EN

We and others have recently obtained data suggesting that cytokine-STAT signaling in many different cell-types is a chaperoned pathway initiated at the level of special­ized plasma membrane microdomains called "rafts" (the "raft-STAT signaling hypoth­esis"). These findings are of broad significance in that all cytokines and growth fac­tors initiate signaling in target cells by interacting with respective cell-surface recep­tors. The new data suggest that raft microdomains represent the units of function at the cell-surface through which ligand-stimulated STAT signaling is initiated. More­over, recent evidence shows the involvement of chaperone proteins in regulating the STAT signaling pathway. These chaperones include the human homolog of the tumorous imaginal disc 1 protein (hTidl) which associates with Janus kinase 2 (JAK2) at the level of the plasma membrane, heat shock protein 90 (HSP90) which as­sociates with STAT3 and STAT1 proteins in caveolin-l-containing raft and cytoplasmic complexes, and glucose regulated protein 58 (GRP58/ER-60/ERp57), a thiol dependent protein-disulfide isomerase, found in association with STAT3 “statosome” complexes in the cytosol and in the raft fraction. We suggest a function of the HSP90 chaperone system in preserving IL-6/STAT3 signaling in liver cells in the context of fever. The identification and function of protein partners associated with specific STAT species in rafts and in cytosolic complexes, and in the efficient departure of cytokine-activated STATs from the cytosolic face of rafts towards the cell nucleus are now areas of active investigation.

Słowa kluczowe

EN

epidermal growth factor; plasma membrane; chaperone; cytokine; heat shock; signal transduction; protein; C-reactive protein; caveolin

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2003
• Tom: 50
• Numer: 3
• Opis fizyczny: p.583-594,fig.

Twórcy

autor

Sehgal P. B.

• New York Medical College, Valhalla, NY 10595, USA

Bibliografia

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