Proba oceny biotransformacyjnej aktywnosci watroby u cielat przy pomocy uproszczonego testu paracetamolowego

• Autorzy: Grochowina B , Janus K.

Warianty tytułu

EN

Trials to evaluate the biotransformation activity of the liver in calves using a simplified paracetamol test

• Języki publikacji: PL

Abstrakty

EN

The aim of the investigation was the modification of the paracetamol (as a model drug) test for calves. We examined if a precise determination of the pharmacokinetics of paracetamol (indirectly the activity of enzymes catalyzing the reaction of phase II of hepatic biotransformation) was possible using a simplified paracetamol test. The experiment was carried out on 15 healthy calves of BW (Black-and-White) breed. Paracetamol (5 mg/kg bw.) was administered per os on the tenth, twentieth and fourteenth days of the calves’ lives. The concentration of a model drug in plasma was determined by the spectrophotometric method in 10, as well as 3 and 4 samples. Pharmacokinetic parameters were estimated using a non-compartmental method, via the TopFit computer program. The values of pharmacokinetic parameters of paracetamol estimated in “simplified variants” significantly correlated (r = 0.874-0.985) with data obtained in a full test. The highest coefficients of the correlation was observed when the concentration of paracetamol was determined at 3, 4, 6 and 8 hours after the model drug administration. Summing up, it was determined that it is possible to evaluate precisely and indirectly the biotransformation activity in calves (activity of UDP-glucuronyltransferase and sulfonyltransferase) using a simplified variant of paracetasmol test, based on the determination of the concentration of the model drug in 3-4 blood samples.

Słowa kluczowe

PL

test paracetamolowy; paracetamol; bydlo; farmakokinetyka; ocena; cieleta; biotransformacja watrobowa

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2006
• Tom: 62
• Numer: 09
• Opis fizyczny: s.1084-1086,tab.,bibliogr.

Twórcy

autor

Grochowina B

• Akademia Rolnicza, ul.Doktora Judyma 2, 71-466 Szczecin

autor

Janus K.

Bibliografia

• 1. Adzu B., Garba M., Haruna A., Maman M., Wambebe C., Gamaniel K.: Effect of niprisan on single oral dose pharmacokinetics of paracetamol in rats. Eur. J. Drug Metab. Pharmacokinet. 2001, 26, 201-204.
• 2. Ali B. H., Cheng Z., Hadrami G., Bashir A. K., McKellar Q. A.: Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats. J. Vet. Pharmacol. Ther. 1996, 19, 238-244.
• 3. Babalola C. P., Oladimeji F. A., Femi-Oyewo M. N.: Pharmacokinetics and saliva secretion of paracetamol in healthy male Nigerians. West. Afr. J. Med. 2004, 23, 10-14.
• 4. Bailie M. B., Federowicz D. A., Dolce K., Kahn C., Mico B. A., Landi M. S.: Pharmacokinetics of acetaminophen, vancomycin and antipyrine in the Hanford miniature swine. Drug. Metab. Disp. 1997, 15, 729-730.
• 5. Bannwarth B., Pehourcq F., Lagrange F., Matoga M., Maury S., Palisson M., Bars M.: Single and multiple dose pharmacokinetic of acetaminophen (paracetamol). J. Rheumatol. 2001, 28, 182-184.
• 6. Flouvat B., Leneveu A., Fitoussi S., Delhotal-Landes B., Gendron A.: Bioequivalence study comparing a new paracetamol solution for injection and paracetamol after single intravenous infusion in healthy subjects. Int. J. Clin. Pharmacol. Ther. 2004, 42, 50-57.
• 7. Janus K., Baranow-Baranowski S., Jakubowska D., Jankowiak D., Skrzypczak W. F.: Próba oceny biotransformacyjnej aktywności wątroby u cieląt przy pomocy uproszczonego testu antypirynowego. Medycyna Wet. 1991, 47, 330-331.
• 8. Janus K., Antoszek J., Muszczyński Z.: Dostępność biologiczna antypiryny u cieląt w pierwszych dwóch miesiącach życia. Medycyna Wet. 1999, 55, 123-125.
• 9. Janus K., Antoszek J.: The effect of sex and age on caffeine pharmacokinetics in cattle. Res. Vet. Sci. 2000, 69, 33-37.
• 10. Janus K., Grochowina B., Antoszek J., Suszycki S., Muszczyński Z.: The effect of food or water deprivation on paracetamol pharmacokinetics in calves. J. Vet. Pharmacol. Ther. 2003, 26, 291-296.
• 11. Kawalek J. C., El-Said K. R.: Maturational development of drug metabolizing enzymes in sheep. Am. J. Vet. Res. 1990, 51, 2044-2050.
• 12. Kearns G. L., Reed M. D.: Clinical pharmacokinetics in infants and children, a reppraisal. Clin. Pharmacokinet. 1999, 17, 29-52.
• 13. Li X. D., Xia S. Q., He P., Han J., Wu M. C.: Conjugation metabolism of acetaminophen and bilirubin in extrahepatic tissues of rats. Life Sci. 2004, 74, 1307-1315.
• 14. Loft S., Haxholdt O., Dossing M.: Antipyrine clearance in children from single saliva samples. Br. J. Clin. Pharmacol. 1995, 19, 698-705.
• 15. McNamara P. J., Burgio D., Yoo S. D.: Pharmacokinetics of acetaminophen, antipyrine and salicylic acid in the lactating and nursing rabbit, with model predictions of milk to serum concentration ratios and neonatal dose. Toxicol. Appl. Pharmacol. 1999, 109, 149-160.
• 16. Monshouwer M., Witkamp R. F., Pijpers A., Verheijden J. H. M., van Miert A. S.: Dose-dependent pharmacokinetic interaction between antipyrine and paracetamol in vivo and in vitro when administered as a cocktail in pig. Xenobiotica 1994, 24, 347-355.
• 17. Monshouwer M., Witkamp R. F., Nijmeijer S. M., Pijpers A., Verheijden J. H. M., van Miert A. S. J. P. A. M.: Selective effects of bacterial infection on the hepatic clearances of caffeine, antipyrine, paracetamol and indocyanine green in the pig. Xenobiotica 1995, 25, 491-499.
• 18. Plewka A., Zielińska-Psuja B., Kowalówka-Zawieja J., Nowaczyk-Dura G., Plewka D., Wiaderkiewicz A., Kamiński M., Orłowski J.: Influence of acetaminophen and trichloroethylene on liver cytochrome P450-dependent monooxygenase system. Acta Bioch. Pol. 2000, 47, 1129-1136.
• 19. Routh J. J., Shane N. A., Arredonde E. G., Paul W. D.: Determination of N-acetyl-p-aminophenol in plasma. Clin. Chem. 1968, 9, 882-889.
• 20. Vesell E. S., Passananti G. T., Glenwright P. A., Dvorchik B. H.: Studies on the disposition of antipyrine, aminopyrine and phenacetin using plasma, saliva and urine. Clin. Pharmacol. Ther. 1995, 18, 259-272.
• 21. Vital-Durand D., Piolat C., Soucheleau J., Baltassat P., Brazier J. L.: Pharmacocinetique de le' antipyrine. Comparaison des concentration totales, libres et salivaires. Therapie 1998, 43, 263-266.