Specific features and roles of renal circulation: angiotensin II revisited

• Autorzy: Sadowski J. , Badzynska B.
• Języki publikacji: EN

Abstrakty

EN

The status of intrarenal circulation determines in part renal excretion, affects body fluid homeostasis and has a role in long term control of arterial blood pressure. The vascular resistance in the renal cortex and medulla is determined by interaction of a vast array of vasoactive hormones and paracrine factors; among these the role of constrictor angiotensin II and dilator prostaglandins and nitric oxide may appear to be dominating. The focus of this review and underlying studies is on the mechanisms whereby the microcirculation of the renal medulla is protected against the vasoconstrictor action of angiotensin II. In anaesthetized normal rats the three mentioned active agents or their inhibitors were applied and total renal blood flow and cortical, outer- and inner medullary laser-Doppler fluxes were determined; in some studies renal tissue nitric oxide was measured using selective electrodes. We conclude that angiotensin II, acting via AT1 receptors, constricts the renal cortical vasculature; in the medulla its action is effectively buffered by prostaglandin E2 but most probably not by nitric oxide.

Słowa kluczowe

EN

renal circulation; intrarenal circulation; angiotensin II; body fluid; homeostasis; arterial blood pressure; renal cortex; microcirculation; renal medulla; prostaglandin E2; prostaglandin; nitric oxide

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2006
• Tom: 57
• Numer: 11
• Opis fizyczny: p.169-178,fig.,ref.

Twórcy

autor

Sadowski J.

• Polish Academy of Sciences, Pawinskiego 5, 02-160 Warsaw, Poland

autor

Badzynska B.