Tempo eliminacji 8-alfa-hydroksymutyliny, markera pozostalosci tiamuliny, u swin

• Autorzy: Zan R , Kowalski C. , Rolinski Z. , Burmanczuk A.

Warianty tytułu

EN

Elimination rates of 8-alpha-hydroxymutilin, a residue marker of tiamulin in pigs

• Języki publikacji: PL

Abstrakty

EN

Tiamulin, a semi-synthetic antibiotic agent, is exclusively used in veterinary medicine and is rapidly distributed in the body and intensively metabolized in the liver. The aim of the study was to estimate the residue levels of tiamulin metabolite in pigs. tissues after oral and intramuscular administration. The experiment was carried out on 38 pbz breed weaners, divided into two groups. One of the groups was administered Tiamowet 45% granulate orally at a dose of 24 mg/kg b.w./day, and the other was administered Tiamowet 200 intramuscularly at a dose of 15 mg/kg b.w./day. Both drugs were taken for 5 days. The weaners from both groups were slaughtered on days 3, 4, 6, 8, 10, 12 and 15 following the end of drug administration. Samples of tested tissues from the livers and muscles were isolated in order to measure the residue marker level. 8-α-hydroxymutilin residues were estimated according to the GC method by Marcus and Sherma in their own modification. A validation method procedure was also carried out. The GC experiment showed that 8-a-hydroxymutilin concentration in the tested muscles attains a lower level than that of MRL i.e. 100 µg/kg on day 10 following intramuscular Tiamowet 200 preparation administration and on day 12 following oral Tiamowet 45% granulate administration.

Słowa kluczowe

PL

8-alfa-hydroksymutylina; pozostalosci lekow weterynaryjnych; farmakokinetyka; eliminacja; trzoda chlewna; analiza chromatograficzna; tiamulina; markery; tempo eliminacji

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2006
• Tom: 62
• Numer: 04
• Opis fizyczny: s.448-451,rys.,tab.,bibliogr.

Twórcy

autor

Zan R

• Akademia Rolnicza, ul.Akademicka 12, 20-033 Lublin

autor

Kowalski C.

autor

Rolinski Z.

autor

Burmanczuk A.

Bibliografia

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