Influence of polychlorinated biphenyls on LH-stimulated secretion of progesterone and oxytocin from bovine luteal cells

• Autorzy: Mlynarczuk J. , Kotwica J.
• Języki publikacji: EN

Abstrakty

EN

Polychlorinated biphenyls (PCBs) due to their lipophilic properties can be easily accumulated in animal and human body and elicit diverse effects causing impairment of reproductive processes. Since these compounds were not be able to affect directly the luteal steroidogenesis, the aim of the present study was to verify hypothesis that PCBs can impair the effect of LH on the secretory function of luteal cells. Bovine luteal cells from different stages of the oestrous cycle (days 1-5, 6-10, 11-15 and 16-18) were exposed for 72h to various congeners of PCBs (PCB 126, PCB 77 and PCB 153) at the doses of 1, 10 or 100 ng/ml, in the presence or absence of LH (100 ng/ml), to determine the possible effect of these compounds on progesterone (P4) and ovarian oxytocin (OT) secretion. Only PCB 77 on days 1-5 and 16-18 increased P4 secretion. All PCBs decreased LH-simulated secretion of P4 from luteal cells obtained from all days of luteal phase. Dioxin-like congener (PCB 126) inhibited (P<0.05) the most evidently LH effect on P4 secretion. All congeners, except the lower doses of PCB 126, increased (P<0.05) OT secretion. They can also increase LH-stimulated secretion of OT, but the effect was dependent on the congener used and on the phase of oestrous cycle. On days 1-5 and 10-15, PCB 126 diminished LH-stimulated effect on OT secretion from luteal cells. PCB 77 (mimickig both dioxin and estradiol effect) in the higher doses, amplified effect of LH-stimulated OT secretion, while on all other days it diminished LH influence. PCB 153, which has estrogen-like properties, amplified LH effect on OT secretion during all studied days of the cycle. We conclude that PCBs (supposedly via estrogen and arylhydrocarbon - AhR receptor) may directly affect LH-stimulated function of CL. This does not appear to be a direct adverse effect on luteal steroidogenesis, but rather indirect on OT secretion from or within CL.

Słowa kluczowe

EN

cow; polychlorinated biphenyl; progesterone; veterinary medicine; animal body; corpus luteum; luteinizing hormone; oxytocin; accumulation

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2006
• Tom: 09
• Numer: 2
• Opis fizyczny: p.101-108,fig.,ref.

Twórcy

autor

Mlynarczuk J.

• Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland

autor

Kotwica J.

Bibliografia

• Adashi EY, Jones PBC, Hsueh AJW (1981) Synergistic ef­fect of glucocorticoids on the stimulation of progesterone production by follicle-stimulating hormone in cultured rat granulosa cells. Endocrinology 106: 1888-1894.
• Alila HW, Dowd JP, Corradino RA, Harris WV, Hansel W (1988) Control of progesterone production in small and large bovine luteal cells separated by flow cytometry. J Reprod Fértil 82: 645-655.
• Andric SA, Kostic TS, Dragisic SM, Andric NL (2000) Acute effects of polychlorinated biphenyl-containing and free transformer fluids on rat testicular steroidogenesis. Environ Health Persp 108: 955-959.
• Augustowska K, Wójtowicz A, Kajta M, Ropstad E, Greg- oraszczuk EL (2001) Polychlorinated biphenyls (PCB 126 and PCB 153) action on proliferation and proges­terone secretion by cultured in vitro porcine luteal cells. Exp Clin Endocr Diab 109: 416-418.
• Bonefeld-Jprgensen EC, Andersen HR, Rasmussen TH, Vinggaard AM (2001) Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and an­drogen receptor activity. Toxicology 158: 141-153. Carlson JC, Kazama N, Hansel W (1971) Effect of LH on peripherial progesterone in intact and hysterectomized heifers. Endocrinology 89: 1530-1533.
• Chen CY, Hamm JT, Hass JR, Albro PW, Birnbaum LS (2002) A mixture of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and non-ortho polichlorinated biphenyls (PCBs) changed the lipid con­tent of pregnant Long Evans rats. Chemosphere 46: 1501-1504.
• Cogliano VJ (1998) Assessing the cancer risk from environ­mental PCBs. Environ Health Persp 10: 378-384.
• Fields MJ, Barros CM, Watkins WB, Fields PA (1992) Char­acterization of large luteal cells and their secretory gran­ules throughout the estrus cycle of the cow. Biol Reprod 46: 535-545.
• Fields MJ, Fields PA (1996) Morphological characteristic of the bovine corpus luteum during the estrous cycle and pregnancy. Theriogenology 45: 1295-1325.
• Frame GM, Cochran JW, Bowadt SS (1996) Complete PCB congener distributions for 17 Aroclor mixtures deter­mined by 3 HRGC system optimized for comprehensive, quantitative, congener-specific analysis. J High Res Chrom 19: 657-668.
• Goldman D, Yawetz A (1992) Interference of poly­chlorinated biphenyls (Aroclor 1254) with membrame regulation of the activities of cytochrome P450 17a-lyase in guinea pig adrenal microsomes. J Steroid Biochem 42: 37-47.
• Harper MJK (1988) Gamete and zygote transport. In: Knob- il E and Neill J (eds) The physiology of reproduction. Raven Press, New York, pp 103-134.
• Ireland JJ, Murphee RL, Coulson PB (1980) Accuracy of predicting stages of bovine oestrous cycle by gross ap­pearance of the corpus luteum. J Dairy Sci 63: 155-160.
• Kamarianos A, Karamanlis X, Goulas P, Theodosiadou E, Smokovitis A (2003) The presence of environmental pol­lutants in follicular fluid of farm animals (cattle, sheep, goats and pigs). Reprod Toxicol 17: 185-195.
• Kotwica J, Skarżyński D (1993) Influence of oxytocin re­moval from corpus luteum on secretory function and dur­ation of the oestrous cycle in cattle. J Reprod Fertil 97: 411-417.
• Kotwica J, Skarżyński D, Jaroszewski J, Bogacki M (1994) Noradrenaline affects secretory functions of corpus luteum independently of prostaglandins in conscious cattle. Prostaglandins 48: 1-10.
• Kotwica J, Skarżyński D Miszkiel G, Melin P, Okuda K (1999) Oxytocin modulates the pulsatile secretion of prostaglandin F2a in initiaded luteolysis in cattle. Res Vet Sci 26: 179-191.
• Leoni V, Fabiani L, Marinelli G, Puccetti G, Tarsitani GF, De Carolis A, Vescia N, Morini A, Aleandri V, Pozzi V (1989) PCB and other organochlori'ne compounds in blood of women with of without miscarriage: a hypothesis of correlation. Ecotox Environ Safe 17: 1-11.
• Li MH, Zhao YD, Hansen LG (1994) Multiple-dose toxi- cokinetic influence on the estrogenicity of 2,2’,4,4’,5,5’,-hexachlorobiphenyl. B Environ Contam Tox 53: 583-590.
• Lind PM, Eriksen EF, Sahlin I, Edlund M, Orberg J (1999) Effects of the antiestrogenic environmental pollutant 3,3’,4,4’,5-pentachlorobiphenyl (PCB-126) in rat bone and uterus: diverging effects in ovariectomized and intact animals. Toxicol Appl Pharm 154: 236-244.
• Lindenau A, Fisher B, Seiler P, Beier HM (1994) Effects of persistent chlorinated hydrocarbons on reproductive tis­sues in female rabbits. Hum Reprod 9: 722-780.
• Luck M (1988) Enhanced secretion of oxytocin from bovine granulose cells treated with adrenal steroids. J Reprod Fertil 83: 901-907.
• Miyamoto A, Schams D (1991) Oxytocin stimulates proges­terone release from microdialysed corpus luteum in vitro. Endocrinology 44: 1163-1170.
• Mlynarczuk J, Amarowicz R, Kotwica J (2003) Effect of polichlorinated biphenyls (Aroclor-1248) on the secretory function of bovine luteal cells affected by LH, noradrena­line and high density lipoproteins. Vet-Med Czech 48: 267-274.
• Mlynarczuk J, Kotwica J (2005) Influence of polychlorinated biphenyls on the secretion of oxytocin from bovine luteal cells and from granulosa cells obtained from the follicles of different size. Pol J Vet Sci 8: 261-267.
• Mlynarczuk J, Niewiadowska A, Kotwica J (2005) Poly­chlorinated biphenyls impair FSH-stimulated effect on the secretion of steroids and oxytocin from cultured bov­ine granulosa cells. B Vet I Puławy 49: 411-417.
• Moore RW, Jefcoate CR, Peterson RE (1991) 2,3,7,8-tet- rachlorodibenzo-p-dioxin inhibits steroidogenesis in the rat testis by inhibiting the mobilization of cholesterol to ctychorome P-450scc. Toxicol Appl Pharm 109, 85-97.
• Nesaretnam K, Corcoran D, Dils RR, Darbre P (1996) 3,4,3’,4’-Tetrachlorobiphenyl acts as an estrogen in vitro and in vivo studies. Mol Endocrinol 10: 923-36.
• Nikula H, Talonpoika T, Kaleva M, Toppari J (1999) Inhibi­tion of hCG-stimuIated steroidogenesis in culturedmouse Leydig tumor cells by bisphenol A and octyl- phenols. Toxicol Appl Pharm 157: 166-73.
• Okuda K, Miyamoto A, Sauerwein H, Schweigert FJ, Schams D (1992) Evidence for oxytocin receptor in cul­tured bovine luteal cells. Biol Reprod 46: 1001-1006.
• Okuda K, Uenoyama Y, Fujita K, Iga K, Sakamoto K, Kimura T (1997) Functional oxytocin receptor in bovine granulosa cells. Biol Reprod 56: 625-631.
• Panasen M (1999) The expression and regulation of drug metabolism in human placenta. Adv Drug Deliver Rev 14: 81-97.
• Pang S, Cao JQ, Katz BH, Hayes CL, Sutter TR, Spink DC 1999) Inductive and inhibitory effects of non-ortho-sub­stituted polichlorinated biphenyls on estrogen metab­olism and human cytochromes P450 1A1 and 1B1. Bio- chem Pharmacol 58: 29-38.
• Pieklo R, Grochowalski A, Gregoraszczuk EL (2000) 2,3,7,8-tetrachlorodibenzo-p-dioxin alters follicular ster­oidogenesis in time- and cell-specific manner. Exp Clin Endoc Diab 108: 299-304.
• Prakash BS, Meyer HD, Schallenberger E, Van de Wiel DF (1987) Development of sensitive enzymeimmunoassay (EIA) for progesterone determination in unextracted bovine plasma using the second antibody technique. J Steroid Biochem 28: 623-627.
• Reinhart KC, Dubey RK, Keller PJ (1999) Xenoestrogens and phytoestrogens induce the synthesis of leukemia in­hibitory factor by human and bovine oviduct. Mol Hum Reprod 5: 115-123.
• Roselli M, Reinhart K, Imthurn B, Keller PJ, Dubey RK 2000) Cellular and biochemical mechanisms by which environmental oestrogens influence reproductive func­tion. Hum Reprod Update 6: 332-350.
• Rowland JC, Gustafsson JA (1997) Aryl hydrocarbon recep­tor-mediated signal transduction. Crit Rev Toxicol 27: 109-134.
• Safe S (1994) Polychlorinated biphenyls (PCBs): environ­mental impact, biochemical and toxic responses, and im­plications for risk assessment. Crit Rev Toxicol 24: 87-149.
• Skarżyński DJ, Okuda K (1999) Sensitivity for bovine cor­pora lutea to prostaglandin F2a is dependent on proges­terone, oxytocin, and prostaglandins. Biol Reprod 60: 1292-1298.
• Stormshak F (2003) Biochemical and endocrine aspects of oxytocin production by the mammalian corpus luteum. Reprod Biol Endocrin 1: 92.
• Taiłam SK, Walton JS, Johnson WH (2000) Effects of oxy­tocin on cloprostenol-induced luteolysis, follicular growth, ovulation and corpus luteum function in heifers. Theriogenology 53: 963-79.
• Trapp M, Baukloh V, Bohnet HG, Hesschen W (1984) Pol­lutants in humans follicular fluid. Fertil Steril 42: 146-148.
• Van Leeuwen FXR (1997) Derivation of toxic equivalency factors (TEFs) for dioxin-like 11 compounds in humans and wildlife. Organohalogen Compounds 34: 237.
• Wróbel M, Kamiński K, Kotwica J (2005) In vitro effect of polychlorinated biphenyls (PCBs) on contractility of bov­ine myometrium from periovulatory stage of the estrous cycle. Reprod Biol 5: 303-319.
• Wróbel M, Kotwica J (2005) Influence of polychlorinated biphenyls (PCBs) and phytoestrogens on prostaglandins F2a and E2 secretion from bovine endometrial cells at postovulatory stage of the estrous cycle. Vet-Med Czech 50: 487-495.
• Zava DT, Blen M, Duwe G (1997) Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture. Environ Health Persp 105: 637-45.