Niektore nowe dane dotyczace wirusologii i immunologii

• Autorzy: Larski Z

Warianty tytułu

EN

Some new data concerning virology and immunology

• Języki publikacji: PL

Abstrakty

EN

Natural killer cells (NK) traditionally classified as belonging to the innate immune system have many similarities with cytotoxic T lymphocytes. An engineered antibody with a single antigen binding fragment (Fab) capable of recognizing two unrelated proteins. SAP-mediated stable adhesion of antigen-specific T and B cells is crucial for generation long-term immunity. Pharmacological enhancing CD8 T cell memory. Interleukin-21 sustains CD8⁺T cell effector activity during chronic viral infection. Failures in HIV-vaccine development.

Słowa kluczowe

PL

wirusologia; immunologia; komorki NK; odpornosc nabyta; mechanizmy odpornosciowe; przeciwciala dwuswoiste; interakcja limfocytow T-B; pamiec immunologiczna; interleukina 21; wirus HIV; szczepionka przeciw AIDS

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2010
• Tom: 66
• Numer: 01
• Opis fizyczny: s.5-8,bibliogr.

Twórcy

autor

Larski Z

• ul.Puszkina 8/10, 10-294 Olsztyn

Bibliografia

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• 3.Bostrom J., Yu S.-F., Kan D., Appleton B. A., Lee C. V., Billeci K., Man W., Peale F., Ross S., Wiesmann C., Fuh G.: Variants of the antibody Herceptin that interacts with HER2 and VEGF at the antigen binding site. Science 2009, 323, 1610-1614.
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• 5.Deenick E. K., Tangye S. G.: Helpful T cells are sticky. Nature 2008, 455, 745-747.
• 6.Elsaesser H., Sauer K., Brooks D. G.: IL-21 is required to control chronic viral infection. Science 2009, 324, 1569-1572.
• 7.Fröhlich A., Kisielow J., Schmitz I., Freigang S., Shamshiev A. T., Weber J., Marsland B. J., Oxenius A., Kopf M.: IL-21 on T cells is critical for sustained functionality and control of chronic viral infection. Science 2009, 324, 1576-1580.
• 8.Johnson L. D. S., Jameson S. C.: A chronic need for IL-21. Science 2009, 324, 1525-1526.
• 9.Medzhitov R., Littman D.: HIV immunology needs new direction. Nature 2008, 455, 591.
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• 11.Parren P. W. H. I., Burton D. R.: Two-in-one designer antibodies. Science 2009, 323, 1567-1568.
• 12.Pearce E. L., Walsh M. C., Cejas P. J., Harms G. M., Shen H., Wang L. S., Jones R. G., Choi Y.: Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 2009, 460, 103-107.
• 13.Prlic M., Bevan M. J.: A metabolic switch to memory. Nature 2009, 460, 41-42.
• 14.Qi H., Cannons J. L., Klauschen F., Schwartzberg P. L., Germain R. N.: SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 2008, 455, 764-769.
• 15.Sun J. C., Beilke J. N., Lanier L. L.: Adaptive immune features of natural killer cells. Nature 2009, 457, 557-561.
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• 17.Yi J. S., Du M., Zajac A. J.: A vital role for interleukin-21 in the control of a chronic viral infection. Science 2009, 324, 1572-1576.